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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Serum concentrations of extracellular fatty acid synthase in patients with steatohepatitis

Judit Marsillach1 / Cristina Oliveras-Ferraros2, 3 / Raúl Beltrán1 / Anna Rull1 / Gerard Aragonès1 / Carlos Alonso-Villaverde1 / Alejandro Vázquez-Martín2, 3 / Jorge Joven1 / Javier A. Menéndez2, 3 / Jordi Camps1

1Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain

2Division of Catalonia, Catalan Institute of Oncology (ICO) Health Services, Spain

3Girona Biomedical Research Institute (IdIBGi), Dr. Josep Trueta University Hospital of Girona, Spain

Corresponding author: Jordi Camps, PhD, Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, C. Sant Joan s/n, 43201 Reus (Catalunya), Spain

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 47, Issue 9, Pages 1097–1099, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2009.259, September 2009

Publication History



Background: Fatty acid synthase (FASN) is an enzyme synthesized by the liver and plays an important role in lipogenesis. The present study aimed to assess whether serum FASN concentrations are altered in patients with chronic liver disease, and to investigate whether its measurement may be a useful tool in the clinical evaluation of this derangement.

Methods: We investigated 93 patients with chronic liver disease (14 minimal change disease, 79 steatohepatitis) and 100 control subjects. Serum FASN concentrations were measured using ELISA.

Results: Patients had a significant increase in serum FASN concentration (p<0.001), which was specifically associated with the hepatic Knodell sub-index III of portal inflammation (p=0.019). In addition, serum FASN concentrations were significantly correlated with the circulating levels of the monocyte chemoattractant protein-1 (MCP-1) (Spearman ρ=0.375; p<0.001) and type III procollagen-N-peptide (P-III-P) (Spearman ρ=0.297; p<0.001).

Conclusions: Serum FASN concentrations are increased in patients with chronic liver impairment, and are associated with specific histological alterations and biochemical markers of portal inflammation. These data suggest that FASN measurement may contribute significantly to the evaluation of these patients.

Clin Chem Lab Med 2009;47:1097–9.

Keywords: chronic hepatitis; fatty acid synthase; fibrogenesis; inflammation; steatosis

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