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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R.


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VKORC1 haplotypes influence the performance characteristics of PIVKAII for screening of hepatocellular carcinoma

Yibo Wang1 / Fang Luo1 / Yi Zheng1 / Xiaohan Fan1 / Jinxing Chen1 / Yu Zhang1 / Rutai Hui

1Sino-German Laboratory for Molecular Medicine, FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China

Corresponding authors: Yibo Wang, FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, P.R. China Phone: +86-10-88398154, Fax: +86-10-68331730, Rutai Hui, FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, P.R. China Phone: +86-10-68333902, Fax: +86-10-68331730,

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 48, Issue 10, Pages 1475–1479, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2010.275, June 2010

Publication History

Received:
2010-02-02
Accepted:
2010-04-21
Published Online:
2010-06-25

Abstract

Background: PIVKAII (protein induced by vitamin K absence), used for screening for hepatocellular carcinoma (HCC), is influenced by vitamin K epoxide reductase complex subunit 1 (VKORC1). VKORC1 haplotype frequency is significantly different in ethnic groups. We evaluated whether VKORC1 haplotypes could influence the performance characteristics of PIVKAII in screening for HCC.

Methods: A total 228 HCC patients and 258 patients with hepatitis B were recruited. Tumor size was measured in 76 patients with HCC. Serum PIVKAII concentrations and VKORC1 haplotype were determined in the cohort. Youden's index and ROC curves were used to compare the performance characteristics of PIVKAII in screening for HCC.

Results: In the HCC group and in patients with hepatitis B, serum PIVKAII concentrations were higher in VKORC1 rs2395612 TT carriers than in CC/CT carriers (50.34±72.18 vs. 11.98±27.45, p<0.05 in HCC group and 1.92±0.52 vs. 1.48±0.36, p<0.01). The estimated optimal cut-off value of PIVKAII for screening HCC was 2.0 and 3.0 ng/mL in CC/CT carriers and TT carriers, respectively. Furthermore, VKORC1 haplotypes also influenced the association of serum PIVKAII concentrations with HCC tumor size in patients with HCC.

Conclusions: VKORC1 haplotypes influence the performance characteristics of PIVKAII for screening of HCC. Thus, measurement could be complementary for PIVKAII in HCC screening.

Clin Chem Lab Med 2010;48:1475–9.

Keywords: hepatocellular carcinoma; PIVKAII (protein induced by vitamin K absence); VKORC1 haplotype

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