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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Hepcidin concentrations and iron homeostasis in preeclampsia

Gergely Toldi1, 2 / Balázs Stenczer2 / Attila Molvarec2 / Zoltán Takáts1 / Gabriella Bekő3 / János Rigó Jr2 / Barna Vásárhelyi4

1First Department of Pediatrics, Semmelweis University, Budapest, Hungary

2First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary

3Department of Central Laboratory, Semmelweis University, Budapest, Hungary

4Research Group of Pediatrics and Nephrology, Hungarian Academy of Sciences, Budapest, Hungary

Corresponding author: Gergely Toldi, First Department of Pediatrics, Semmelweis University, Bókay u. 53–54, 1083 Budapest, Hungary Phone: +36-20-4367181, Fax: +36-1-3138212,

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 48, Issue 10, Pages 1423–1426, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2010.290, July 2010

Publication History

Received:
2010-03-24
Accepted:
2010-05-03
Published Online:
2010-07-14

Abstract

Background: Plasma iron is increased in preeclampsia (PE) when compared to healthy pregnant women. This is in contrast to inflammation characteristic for PE. The link between iron homeostasis and inflammation is hepcidin. Our goal was to describe hepcidin concentrations and its association with iron homeostasis in PE.

Methods: We obtained peripheral blood samples from 30 preeclamptic [gestational age: 36.5 (24–40) weeks] and 37 healthy pregnant women [gestational age: 36 (28–39) weeks] to determine plasma hepcidin and interleukin-6 (IL-6) concentrations, complete blood cell counts and parameters of iron homeostasis [plasma iron, transferrin and ferritin levels and total iron binding capacity (TIBC)]. Hepcidin was measured using mass spectrophotometry. The Mann-Whitney test was used for statistical analysis.

Results: Plasma hepcidin, IL-6, iron and ferritin concentrations were increased (p<0.05 for all), whereas plasma transferrin, TIBC and mean corpuscular hemoglobin concentrations were lower (p<0.05 for all) in PE compared to healthy pregnant women. No differences were seen in the other parameters investigated.

Conclusions: Plasma iron concentrations are increased despite high hepcidin concentrations in PE. This might indicate a resistance to the iron-decreasing action of hepcidin.

Clin Chem Lab Med 2010;48:1423–6.

Keywords: hepcidin; interleukin-6; iron homeostasis; preeclampsia

Citing Articles

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[1]
Candan Iltemir Duvan, Serap Simavli, Esra Aktepe Keskin, Yuksel Onaran, Nilgun Ozturk Turhan, and Cemile Koca
Hypertension in Pregnancy, 2015, Volume 34, Number 2, Page 145
[2]
Serap Simavli, Aysel Uysal Derbent, Esra Aktepe Keskin, Ilknur Inegol Gumus, Sema Uysal, and Nilgun Turhan
The Journal of Maternal-Fetal & Neonatal Medicine, 2015, Volume 28, Number 7, Page 854
[3]
Cui Xie, Mian Zhi Yao, Jiang Bo Liu, and Li Kuan Xiong
Cytokine, 2011, Volume 56, Number 3, Page 550
[4]
[5]
Gergely Toldi, Edina Bíró, Balázs Szalay, Balázs Stenczer, Attila Molvarec, János Rigó, Barna Vásárhelyi, and Gabriella Bekõ
Clinical Chemistry and Laboratory Medicine, 2011, Volume 49, Number 11
[6]
Béla Gyarmati, Eszter Szabó, Balázs Szalay, Noémi Czuczy, Gergely Toldi, Áron Cseh, Barna Vásárhelyi, and Zoltán Takáts
Journal of Obstetrics and Gynaecology Research, 2011, Volume 37, Number 11, Page 1620

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