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Publication Date:
October 2010
ISSN:
1437-4331
DOI:
10.1515/cclm.2011.015

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Clinical Chemistry and Laboratory Medicine (CCLM)

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Evaluation of ovarian cancer biomarkers in subjects with benign asbestos-related pleural diseases

Eun-Kee Park1, 2 / Anthony R. Johnson3 / Deborah H. Yates1 / 2

1Department of Thoracic Medicine, St. Vincent's Hospital, Darlinghurst, Sydney, NSW 2010, Australia

2Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, NSW 2031, Australia

3Department of Respiratory Medicine, Liverpool Hospital, Sydney, NSW 2170, Australia

Corresponding author: Paul S. Thomas, MD, Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, NSW 2031, Australia Phone: +61-2-9382-4620, Fax: +61-2-9382-4627

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 49, Issue 1, Pages 147–150, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/cclm.2011.015, October 2010

Publication History:
Received:
2010-05-04
Accepted:
2010-07-22
Published Online:
2010-10-20

Abstract

Background: Mesothelioma and ovarian cancer have been reported to have a similar pathogenesis, and for this reason it was hypothesized that there may be biomarkers in common and possibly associated with benign pleural diseases caused by asbestos exposure.

Methods: Serum biomarkers including insulin-like growth factor-II (IGF-II), leptin, prolactin and vascular endothelial growth factor (VEGF) were measured in an observational study of subjects with benign asbestos-related pleural diseases (BARPD) (n=24) and healthy subjects with an asbestos exposure history (n=12).

Results: Mean serum IGF-II and VEGF concentration in healthy subjects with a history of asbestos exposure were higher than those with BARPD. Mean serum concentrations of leptin and prolactin showed opposite trends when compared to IGF-II and VEGF concentrations among these groups.

Conclusions: The results suggest that IGF-II and VEGF concentrations are lower in BARPD, similar to studies of ovarian cancer. This finding warrants further investigation with malignant asbestos-related diseases.

Keywords: asbestos; benign asbestos-related diseases; biomarker; ovarian cancer

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