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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

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Glycated albumin may be a possible alternative to hemoglobin A1c in diabetic patients with anemia

Sollip Kim1 / 2 / Sail Chun2 / Woochang Lee2 / Hae-il Park3

1Department of Laboratory Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea

2Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea

3Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Bucheon St. Mary’s Hospital, Bucheon, Republic of Korea

Corresponding author: Won-Ki Min, MD, PhD, Department of Laboratory Medicine, Asan Medical Center, Asanbyeongwon-gil 86, Songpa-Gu, Seoul 138-736, Republic of Korea Phone: +82-2-3010-4503, Fax: +82-2-478-0884

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 49, Issue 10, Pages 1743–1747, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2011.646, June 2011

Publication History

Published Online:


Background: We assessed whether glycated albumin (GA) is a useful glycemic indicator in diabetic patients with anemia who did not undergo dialysis.

Methods: Hemoglobin A1c (HbA1c) and GA were simultaneously measured in 370 diabetic subjects who had not undergone dialysis. The relationship between GA and HbA1c was evaluated in patients with and without anemia.

Results: GA-to-HbA1c ratio was significantly higher (3.3±0.7 vs. 2.8±0.5, p<0.001) and the regression slope between GA and HbA1c was steeper in diabetic patients with than in those without anemia (6.2 vs. 4.2, p<0.001).

Conclusions: HbA1c was underestimated in diabetic patients with anemia than in those without anemia, with the degree of underestimation increasing as glycemic control became poorer. GA may more accurately assess glycemic control in diabetic patients with anemia than HbA1c.

Keywords: anemia; diabetes mellitus; glycated albumin; HbA1c; macroalbuminuria

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