Prognostic, therapeutic and diagnostic potential of microRNAs in non-small cell lung cancer : Clinical Chemistry and Laboratory Medicine

www.degruyter.com uses cookies, tags, and tracking settings to store information that help give you the very best browsing experience.
To understand more about cookies, tags, and tracking, see our Privacy Statement
I accept all cookies for the De Gruyter Online site

Jump to ContentJump to Main Navigation

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.


IMPACT FACTOR 2014: 2.707
Rank 6 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 0.741
Source Normalized Impact per Paper (SNIP) 2014: 1.011
Impact per Publication (IPP) 2014: 2.310

VolumeIssuePage

Issues

30,00 € / $42.00 / £23.00

Get Access to Full Text

Prognostic, therapeutic and diagnostic potential of microRNAs in non-small cell lung cancer

Athina Markou1 / 2 / 1

1Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, Athens, Greece

2Genomic Assays – R&D, Life Technologies, Foster City, CA, USA

Corresponding authors: Yu Liang, Genomic Assays – R&D, Life Technologies, Foster City, CA 94404, USA Evi Lianidou, Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, 15771, Athens, Greece

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 49, Issue 10, Pages 1591–1603, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2011.661, July 2011

Publication History

Received:
2011-03-17
Accepted:
2011-06-02
Published Online:
2011-07-18

Abstract

Non-small cell lung carcinomas (NSCLC) account for about 80% of lung cancers and their remarkable heterogeneity manifests in histology, pathogenesis, prognosis, and response to treatments. Recent advances in molecular characterization help stratifying NSCLC patients for their potential benefit from targeting therapies. However, the fundamental mechanisms underlying the tumoral heterogeneity remain poorly understood. Expression profiling of many microRNAs (miRNAs) in various normal and disease tissues demonstrated unique spatial and temporal expression patterns and some miRNAs have been functionally characterized as oncogenes or tumor suppressor genes. Genome-wide screening identified specific miRNA expression signatures associated with clinical outcome of NSCLC patients. A group of miRNAs that has enriched expression in normal lung was found down regulated in NSCLC and may function as tumor suppressor genes. In this review we: a) summarize the current understanding of the critical role that miRNAs play in normal cell functions and in disease biology especially in lung cancer tumorigenesis, b) highlight their potential as biomarkers for lung cancer risk stratification, outcome prediction and classification of histologic subtypes, c) critically assess current knowledge on lung-enriched miRNAs and expression of their predicted target genes in NSCLC and d) evaluate their potential as circulating biomarkers and therapeutic targets in lung cancer.

Keywords: diagnosis; microRNAs; non-small cell lung cancer; prognosis; tumor biomarkers

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Lili Jiang, Dan Zang, Songgang Yi, Xiaofen Li, Changshan Yang, Xiaoxian Dong, Chong Zhao, Xiaoying Lan, Xin Chen, Shouting Liu, Ningning Liu, Hongbiao Huang, Xianping Shi, Xuejun Wang, and Jinbao Liu
Scientific Reports, 2016, Volume 6, Page 21565
[2]
Roghayeh Sheervalilou, Khalil Ansarin, Sedigheh Fekri Aval, Sakine Shirvaliloo, Yones Pilehvar-soltanahmadi, Mozhdeh Mohammadian, Nosratollah Zarghami, and Liron Pantanowitz
Diagnostic Cytopathology, 2016, Page n/a
[3]
Tamara Mirzapoiazova, Frances E. Lennon, Bolot Mambetsariev, Michael Allen, Jacob Riehm, Valeriy A. Poroyko, and Patrick A. Singleton
International Journal of Cell Biology, 2015, Volume 2015, Page 1
[4]
Huiyin Lan, Haiqi Lu, Xian Wang, and Hongchuan Jin
BioMed Research International, 2015, Volume 2015, Page 1
[5]
Florence Sonneville, Manon Ruffin, Loïc Guillot, Nathalie Rousselet, Philippe Le Rouzic, Harriet Corvol, and Olivier Tabary
The American Journal of Pathology, 2015, Volume 185, Number 4, Page 897
[6]
Raihana Maqbool and Mahboob Ul Hussain
Cell and Tissue Research, 2014, Volume 358, Number 1, Page 1
[7]
A. Markou, I. Sourvinou, P.A. Vorkas, G.M. Yousef, and E. Lianidou
Lung Cancer, 2013, Volume 81, Number 3, Page 388
[8]
Su-Chen Li, Ahmed Essaghir, Cécile Martijn, Ricardo V Lloyd, Jean-Baptiste Demoulin, Kjell Öberg, and Valeria Giandomenico
Modern Pathology, 2013, Volume 26, Number 5, Page 685
[9]
Daniela Petriella, Domenico Galetta, Vincenza Rubini, Eufemia Savino, Angelo Paradiso, Giovanni Simone, and Stefania Tommasi
Molecular Biotechnology, 2013, Volume 54, Number 3, Page 913
[10]
Divya Kesanakurti, Dilip Rajasekhar Maddirela, Subramanyam Chittivelu, Jasti S. Rao, and Chandramu Chetty
Biochemical and Biophysical Research Communications, 2013, Volume 434, Number 3, Page 627
[11]
Hye-Suk Han, Jieun Yun, Sung-nam Lim, Joung-Ho Han, Ki Hyeong Lee, Seung Taik Kim, Min-Ho Kang, Seung-Myoung Son, Yong-Moon Lee, Song-Yi Choi, Seok Joong Yun, Wun-Jae Kim, and Ok-Jun Lee
International Journal of Cancer, 2013, Volume 133, Number 3, Page 645
[12]
Sichuan Xi, Hong Xu, Jigui Shan, Yongguang Tao, Julie A. Hong, Suzanne Inchauste, Mary Zhang, Tricia F. Kunst, Leandro Mercedes, and David S. Schrump
Journal of Clinical Investigation, 2013, Volume 123, Number 3, Page 1241
[13]
C. V. Diaz-Garcia, A. Agudo-Lopez, C. Perez, J. A. Lopez-Martin, J. L. Rodriguez-Peralto, J. de Castro, A. Cortijo, M. Martinez-Villanueva, L. Iglesias, R. Garcia-Carbonero, J. A. Fresno Vara, A. Gamez-Pozo, J. Palacios, H. Cortes-Funes, L. Paz-Ares, and M. T. Agullo-Ortuno
Carcinogenesis, 2013, Volume 34, Number 5, Page 1031
[14]
Y B Im, M K Jee, J I Choi, H T Cho, O H Kwon, and S K Kang
Cell Death and Disease, 2012, Volume 3, Number 11, Page e426
[15]
Young Bin Im, Min Ki Jee, Jin Sun Jung, Jee In Choi, Jin Hwa Jang, and Soo Kyung Kang
Antioxidants & Redox Signaling, 2012, Volume 16, Number 10, Page 1046
[16]
Jun Shen and Feng Jiang
Expert Opinion on Medical Diagnostics, 2012, Volume 6, Number 3, Page 197
[17]
Lihua Li, Aaron L Sarver, Setara Alamgir, and Subbaya Subramanian
Laboratory Investigation, 2012, Volume 92, Number 4, Page 571
[18]
Betty C. Tong and David H. Harpole
Surgical Oncology Clinics of North America, 2012, Volume 21, Number 1, Page 161

Comments (0)

Please log in or register to comment.