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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Whitfield, John B.

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Urinary stone composition in pediatric patients: a retrospective study of 205 cases

1 / Abdellatif Nouri2 / Mohamed Fadhel Najjar1

1Department of Biochemistry and Toxicology, University Hospital, Monastir, Tunisia

2Department of Pediatric Surgery, University Hospital, Monastir, Tunisia

Corresponding author: Akram Alaya, Department of Biochemistry and Toxicology, University Hospital, Monastir 5000, Tunisia Phone: +216 98 85 21 76, Fax: +216 73 46 06 78

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 49, Issue 2, Pages 243–248, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2011.046, December 2010

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Background: Stone composition has changed substantially over the past decades in developed countries. We studied urinary stone composition in Tunisian children.

Methods: We studied 205 children ranging from 3 months to 16 years old age and who were diagnosed as having urinary stones (122 boys and 83 girls). Stone analysis was performed respectively using a stereomicroscope and by infrared spectroscopy to determine, respectively, the morphological type and molecular composition of each.

Results: Of 205 stones analysed, 77 (37.5%) were composed of a single constituent. Calcium oxalate (CaOx) stone were predominant, being a constituent of 54.7% of stones, followed by calcium phosphate and purines; 14.6% of cases. Calcium oxalate monohydrate was more frequently seen in girls (p<0.01), while struvite was more common in boys (p<0.001). Teenagers were more affected by whewellite stones compared with infants (p<0.05). Purine stones were predominant in 20% of cases, but its prevalence decreased with age.

Conclusions: The increase in calcium oxalate stones in school age children and the decrease of struvite and purines stones confirm the change in the etiology of urolithiasis with respect to age.

Keywords: children; infrared spectroscopy; stone

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