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Publication Date:
February 2011
ISSN:
1437-4331
DOI:
10.1515/cclm.2011.080

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Clinical Chemistry and Laboratory Medicine (CCLM)

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Parkinson's disease – the continuing search for biomarkers

1, 2, a / Andrew W. Michell2, a / Roger A. Barker1, 2

1Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK

2Department of Clinical Neurosciences, Addenbrooke's Hospital, Cambridge, UK

aD.P. Breen and A.M. Michell contributed equally to this work.

Corresponding author: Dr. David P. Breen, Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, ED Adrian Building, Forvie Site, Robinson Way, Cambridge, CB2 0PY, UK

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 49, Issue 3, Pages 393–401, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/cclm.2011.080, February 2011

Publication History:
Received:
2010-07-29
Accepted:
2010-11-10
Published Online:
2011-02-03

Abstract

There is currently no well-established biomarker for Parkinson's disease. The need to better diagnose the condition, define the subtypes of disease, and follow its course independent of any symptomatic drug effects is well-established. In this review, we will begin by reviewing the evidence for biological fluid biomarkers in Parkinson's disease. We will then touch upon the role of brain imaging in diagnosis and defining prognosis, as well as the value of studying motor phenotype and its potential applications for characterising Parkinson's disease subtypes with differing natural histories.

Keywords: biomarkers; motor phenotype; neurology; Parkinson's disease

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