Jump to ContentJump to Main Navigation

Online

249,00 € / $374.00*

* Prices subject to change. Shipping costs will be added if applicable.
Publication Date:
May 2011
ISSN:
1437-4331
DOI:
10.1515/cclm.2011.618

See all formats and pricing

Online
Individual Subscription Online only
Euro [D] 249.00
RRP for USA, Canada, Mexico
US$ 374.00 *
Print
Individual Subscription Online only
Euro [D] 1577.00
RRP for USA, Canada, Mexico
US$ 2365.00 *
Print + Online
Individual Subscription Online only
Euro [D] 1893.00
RRP for USA, Canada, Mexico
US$ 2838.00 *
*Prices subject to change. Shipping costs will be added if applicable.

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the International Federation of Clinical Chemistry and Laboratory Medicine and the European Federation of Clinical Chemistry and Laboratory Medicine

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Lippi, Giuseppe / Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Melichar, Bohuslav / Siest, Gérard / Whitfield, John B. / Abi Fadel, Marianne / Alvarez Menendez, Francisco V. / Azzazy, Hassan M.E. / Diamandis, Eleftherios P. / Eckardstein, Arnold / Favaloro, Emmanuel J. / Griesmacher, Andrea / Herrmann, Wolfgang / Hoffmann, Johannes J.M.L. / Hooijkaas, Herbert / Ichihara, Kiyoshi / Kaabachi, Naziha / Kim, Jeong-Ho / Korte, Wolfgang / Kroupis, Christos / Lai, Leslie Charles / Lam, Wai Kei Christopher / Marc, Janja / Miyoshi, Eiji / Özben, Tomris / Palicka, Vladimir / Panteghini, Mauro / Queralto, Jose M. / Scartezini, Marileia / Simundic, Ana-Maria / Tsongalis, Gregory J. / Wallemacq, Pierre E. / Yan, Shengkai / Young, Ian S. / Chiu, Rossa Wai Kwun / Ghosh, Debabrata / Kappelmayer, Janos / Lehmann, Sylvain / Sypniewska, Grazyna

12 Issues per year

Increased IMPACT FACTOR 2011: 2.150
Rank 10 out of 32 in category Medical Laboratory Technology in the 2011 Thomson Reuters Journal Citation Report/Science Edition

VolumeIssuePage

Issues

Ahead of print >

Volume 51 (2013)

Volume 50 (2012)

Volume 49 (2011)

Volume 48 (2010)

Volume 47 (2009)

Volume 46 (2008)

Volume 45 (2007)

Volume 44 (2006)

Volume 43 (2005)

Volume 42 (2004)

Volume 41 (2003)

Volume 40 (2002)

Volume 39 (2001)

Volume 38 (2000)

Volume 37 (1999)

Volume 36 (1998)

Volume 35 (1997)

Volume 34 (1996)

Volume 33 (1995)

Volume 32 (1994)

Volume 31 (1993)

Volume 30 (1992)

Volume 29 (1991)

Volume 28 (1990)

Volume 27 (1989)

Volume 26 (1988)

Volume 25 (1987)

Volume 24 (1986)

Volume 23 (1985)

Volume 22 (1984)

Volume 21 (1983)

Volume 20 (1982)

Volume 19 (1981)

Volume 18 (1980)

Volume 17 (1979)

Volume 16 (1978)

Volume 15 (1977)

Volume 14 (1976)

Volume 13 (1975)

Volume 12 (1974)

Volume 11 (1973)

Volume 10 (1972)

Volume 9 (1971)

Volume 8 (1970)

Volume 7 (1969)

Volume 6 (1968)

Volume 5 (1967)

Volume 4 (1966)

Volume 3 (1965)

Volume 2 (1964)

Volume 1 (1963)

Most Downloaded Articles

  1. Global DNA hypomethylation in cancer: review of validated methods and clinical significance by Toraño, Estela G./ Petrus, Sandra/ Fernandez, Agustin F. and Fraga, Mario F.
  2. Diabetes as a complication of adipose tissue dysfunction. Is there a role for potential new biomarkers? by Bergmann, Katarzyna and Sypniewska, Grazyna
  3. Preanalytical quality improvement: in quality we trust by Lippi, Giuseppe/ Becan-McBride, Kathleen/ Behúlová, Darina/ Bowen, Raffick A./ Church, Stephen/ Delanghe, Joris/ Grankvist, Kjell/ Kitchen, Steve/ Nybo, Mads/ Nauck, Matthias/ Nikolac, Nora/ Palicka, Vladimir/ Plebani, Mario/ Sandberg, Sverre and Simund...
  4. The theory of reference values: an unfinished symphony by Siest, Gerard/ Henny, Joseph/ Gräsbeck, Ralph/ Wilding, Peter/ Petitclerc, Claude/ Queraltó, Josep M. and Petersen, Peter Hyltoft
  5. The measurement of 25-hydroxy vitamin D – an analytical challenge by Herrmann, Markus

30,00 € / $42.00*

30,00 € / $42.00

Get Access to Full Text
(PDF, 449 KB)

Translating pharmacogenetics into clinical practice: interleukin (IL)28B and inosine triphosphatase (ITPA) polymophisms in hepatitis C virus (HCV) infection

1, a / Erica Villa2, a / Cristina Rota1 / Rosina Critelli2 / Tommaso Trenti1

1Clinical Pathology-Toxicology, Ospedale Civile S. Agostino-Estense, Modena, Italy

2Department of Gastroenterology, Azienda Ospedaliera-Universitaria, University of Modena and Reggio Emilia, Modena, Italy

aE. Cariani and E. Villa have contributed equally to the paper.

Corresponding author: Elisabetta Cariani, Clinical Pathology-Toxicology, Ospedale S. Agostino-Estense, via Giardini 1355, 41100 Modena, Italy Phone: +39 0593961426, Fax: +39 0593961249

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 49, Issue 8, Pages 1247–1256, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/cclm.2011.618, May 2011

Publication History:
Received:
2011-01-17
Accepted:
2011-03-17
Published Online:
2011-05-25

Abstract

Hepatitis C virus (HCV) infection is frequently characterized by evolution to chronicity and by a variable clinical course of the disease. The clinical heterogeneities of HCV infection and the imperfect predictability of the response to interferon (IFN) have suggested the need to search for a genetic basis of clinical features. This led to the discovery of genetic polymorphisms playing a major role in the evolution of infection, as well as on treatment response and adverse effects. This review will cover recent reports on the subject, focusing on the potential use of the new genetic markers in the diagnostic algorithm for the stratification of patients for personalized antiviral regimens.

Keywords: hepatitis C virus (HCV); inosine triphosphatase (ITPA); interferon (IFN); interleukin 28B (IL28B); polymorphism (SNP); ribavirin (RBV)

Comments (0)

Please log in or register to comment.