Jump to ContentJump to Main Navigation

Online

249,00 € / $374.00*

* Prices subject to change. Shipping costs will be added if applicable.
Publication Date:
September 2011
ISSN:
1437-4331
DOI:
10.1515/cclm.2011.707

See all formats and pricing

Online
Individual Subscription Online only
Euro [D] 249.00
RRP for USA, Canada, Mexico
US$ 374.00 *
Print
Individual Subscription Online only
Euro [D] 1577.00
RRP for USA, Canada, Mexico
US$ 2365.00 *
Print + Online
Individual Subscription Online only
Euro [D] 1893.00
RRP for USA, Canada, Mexico
US$ 2838.00 *
*Prices subject to change. Shipping costs will be added if applicable.

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the International Federation of Clinical Chemistry and Laboratory Medicine and the European Federation of Clinical Chemistry and Laboratory Medicine

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Lippi, Giuseppe / Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Melichar, Bohuslav / Siest, Gérard / Whitfield, John B. / Abi Fadel, Marianne / Alvarez Menendez, Francisco V. / Azzazy, Hassan M.E. / Diamandis, Eleftherios P. / Eckardstein, Arnold / Favaloro, Emmanuel J. / Griesmacher, Andrea / Herrmann, Wolfgang / Hoffmann, Johannes J.M.L. / Hooijkaas, Herbert / Ichihara, Kiyoshi / Kaabachi, Naziha / Kim, Jeong-Ho / Korte, Wolfgang / Kroupis, Christos / Lai, Leslie Charles / Lam, Wai Kei Christopher / Marc, Janja / Miyoshi, Eiji / Özben, Tomris / Palicka, Vladimir / Panteghini, Mauro / Queralto, Jose M. / Scartezini, Marileia / Simundic, Ana-Maria / Tsongalis, Gregory J. / Wallemacq, Pierre E. / Yan, Shengkai / Young, Ian S. / Chiu, Rossa Wai Kwun / Ghosh, Debabrata / Kappelmayer, Janos / Lehmann, Sylvain / Sypniewska, Grazyna

12 Issues per year

Increased IMPACT FACTOR 2011: 2.150
Rank 10 out of 32 in category Medical Laboratory Technology in the 2011 Thomson Reuters Journal Citation Report/Science Edition

VolumeIssuePage

Issues

Ahead of print >

Volume 51 (2013)

Volume 50 (2012)

Volume 49 (2011)

Volume 48 (2010)

Volume 47 (2009)

Volume 46 (2008)

Volume 45 (2007)

Volume 44 (2006)

Volume 43 (2005)

Volume 42 (2004)

Volume 41 (2003)

Volume 40 (2002)

Volume 39 (2001)

Volume 38 (2000)

Volume 37 (1999)

Volume 36 (1998)

Volume 35 (1997)

Volume 34 (1996)

Volume 33 (1995)

Volume 32 (1994)

Volume 31 (1993)

Volume 30 (1992)

Volume 29 (1991)

Volume 28 (1990)

Volume 27 (1989)

Volume 26 (1988)

Volume 25 (1987)

Volume 24 (1986)

Volume 23 (1985)

Volume 22 (1984)

Volume 21 (1983)

Volume 20 (1982)

Volume 19 (1981)

Volume 18 (1980)

Volume 17 (1979)

Volume 16 (1978)

Volume 15 (1977)

Volume 14 (1976)

Volume 13 (1975)

Volume 12 (1974)

Volume 11 (1973)

Volume 10 (1972)

Volume 9 (1971)

Volume 8 (1970)

Volume 7 (1969)

Volume 6 (1968)

Volume 5 (1967)

Volume 4 (1966)

Volume 3 (1965)

Volume 2 (1964)

Volume 1 (1963)

Most Downloaded Articles

  1. Global DNA hypomethylation in cancer: review of validated methods and clinical significance by Toraño, Estela G./ Petrus, Sandra/ Fernandez, Agustin F. and Fraga, Mario F.
  2. Diabetes as a complication of adipose tissue dysfunction. Is there a role for potential new biomarkers? by Bergmann, Katarzyna and Sypniewska, Grazyna
  3. Preanalytical quality improvement: in quality we trust by Lippi, Giuseppe/ Becan-McBride, Kathleen/ Behúlová, Darina/ Bowen, Raffick A./ Church, Stephen/ Delanghe, Joris/ Grankvist, Kjell/ Kitchen, Steve/ Nybo, Mads/ Nauck, Matthias/ Nikolac, Nora/ Palicka, Vladimir/ Plebani, Mario/ Sandberg, Sverre and Simund...
  4. The theory of reference values: an unfinished symphony by Siest, Gerard/ Henny, Joseph/ Gräsbeck, Ralph/ Wilding, Peter/ Petitclerc, Claude/ Queraltó, Josep M. and Petersen, Peter Hyltoft
  5. The measurement of 25-hydroxy vitamin D – an analytical challenge by Herrmann, Markus

30,00 € / $42.00*

30,00 € / $42.00

Get Access to Full Text
(PDF, 285 KB)

The human epidermal growth factor receptor 2 (HER2)

1 / Gregory J. Tsongalis1

1Department of Pathology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center and Norris Cotton Cancer Center, Lebanon, NH, USA

Corresponding author: Laura J. Tafe, MD, Department of Pathology, Dartmouth-Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA Phone: +1-603-650-7211, Fax: 1-603-650-7214

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 50, Issue 1, Pages 23–30, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/cclm.2011.707, September 2011

Publication History:
Received:
2011-06-08
Accepted:
2011-08-12
Published Online:
2011-09-15

Abstract

The declared “war on cancer” aimed to eradicate this disease using our knowledge of cancer cell biology to develop novel therapeutics. One such target of these novel therapies has been the human epidermal growth factor receptor 2 (HER2) gene. Unique in the approach to abolishing function of this gene coded receptor, it was the first target of new monoclonal antibody therapy targeting the extracellular receptor and now also a target of small molecule drugs against the intracellular tyrosine kinase domain. In this instance, it was also one of the first applications of personalized medicine requiring companion diagnostics. In this manuscript, we review the biology and clinical applications of HER2 as a biomarker of disease and as a therapeutic target.

Keywords: breast cancer; gastric cancer; Her2; lapatinib; trastuzumab

Comments (0)

Please log in or register to comment.