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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R.


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Gold nanoparticles in the clinical laboratory: principles of preparation and applications

1, 2 / Mai M.H. Mansour1 / Tamer M. Samir1, 3 / Ricardo Franco4

1Yousef Jameel Science and Technology Research Center, The American University in Cairo, New Cairo, Egypt

2Department of Chemistry, The American University in Cairo, New Cairo, Egypt

3Faculty of Pharmacy, Misr University for Science and Technology, October City, Egypt

4REQUIMTE, Departmento de Química, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, Campus de Caparica, Lisboa, Portugal

Corresponding author: Dr. Hassan M.E. Azzazy, The American University in Cairo, P.O. Box 74, New Cairo, 11835, Egypt Phone: +202 2615-2559, Fax: +202 2795 7565

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM). Volume 50, Issue 2, Pages 193–209, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/cclm.2011.732, October 2011

Publication History

Received:
2011-01-23
Accepted:
2011-08-28
Published Online:
2011-10-06

Abstract

In order to meet the challenges of effective healthcare, the clinical laboratory is constantly striving to improve testing sensitivity while reducing the required time and cost. Gold nanoparticles (AuNPs) are proposed as one of the most promising tools to meet such goals. They have unique optophysical properties which enable sensitive detection of biomarkers, and are easily amenable to modification for use in different assay formats including immunoassays and molecular assays. Additionally, their preparation is relatively simple and their detection methods are quite versatile. AuNPs are showing substantial promise for effective practical applications and commercial utilization is already underway. This article covers the principles of preparation of AuNPs and their use for development of different diagnostic platforms.

Keywords: assay; bio-barcode; diagnostics; gold nanoparticles; immunoassay; molecular assay; nanomedicine

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