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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Serum cystatin C is an early biomarker for assessment of renal function in burn patients

Xiaoyan Cai1 / 2 / Lianduo Lin1 / Yudong Feng1 / Naxi Zhou1 / Qifeng Mai1

1Burns Department, the First People’s Hospital of Shunde (The Affiliated Hospital at Shunde, Southern Medical University), Foshan, P.R. China

2Department of Urology, The First People’s Hospital of Shunde, Foshan, P.R. China

Corresponding author: Professor Zhaolin Long, Department of Urology, the First People’s Hospital of Shunde (The Affiliated Hospital at Shunde, Southern Medical University), Penglai Road, Daliang Town, Shunde District, Foshan, Guangdong 528300, P.R. China Phone: +86 757 22318701, Fax: +86 757 22223899

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 50, Issue 4, Pages 667–671, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/cclm-2011-0838, January 2012

Publication History

Received:
2011-11-19
Accepted:
2011-12-02
Published Online:
2012-01-19

Abstract

Background: Early detection of renal dysfunction is important in burn patients. This study evaluated whether serum cystatin C (CysC) is a potentially accurate and sensitive marker for identification of reduced glomerular filtration rate (GFR) and the risk factors of impaired renal function in major burn patients.

Methods: A total of 48 adult patients with major burn injury were enrolled. Renal function was assessed using serum creatinine (sCr), 24-h urinary creatinine clearance (24-hCrCl), sCr-based formulae and CysC-based formulae on the second day and seventh day post-burn.

Results: There was a high prevalence (27.1%) of acute impaired renal function in major burn patients in the first week post-burn. CysC-based formulae for estimated GFR (eGFR) are more accurate and sensitive for detection of impaired renal function than sCr-based formulae. Multivariate logistic regression analysis demonstrated that age (OR, 2.08; 95% CI 1.26–4.77) and the percentage of burn area (OR, 3.41; 95% CI 1.64–6.95) were independent risk factors of impaired renal function.

Conclusions: The results of this study suggest that CysC is a more accurate and sensitive marker for identification of acute impaired renal function in major burn patients than sCr. It is important to measure CysC and calculate eGFR to prevent acute renal failure and modify drug doses in burn patients, especially those of older age and with major burn areas.

Keywords: burn; cystatin C; glomerular filtration rate; serum creatinine

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[1]
Nguessan Aimé Brou, Evelyne Jacqz-Aigrain, and Wei Zhao
British Journal of Clinical Pharmacology, 2015, Volume 80, Number 1, Page 20
[2]
Haejun Yim, Dohern Kym, Dong Kook Seo, Jaechul Yoon, Hyeong-Tae Yang, Jeonghwan Lee, Yong-Suk Cho, Jun Hur, Wook Chun, and Seong-Woo Han
European Journal of Clinical Investigation, 2015, Volume 45, Number 6, Page 594
[3]
Dohern Kym, Yong-Suk Cho, Jaechul Yoon, Haejun Yim, and Hyeong-Tae Yang
Annals of Surgical Treatment and Research, 2015, Volume 88, Number 5, Page 281

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