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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R.


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The predictive value of immature granulocyte count and immature myeloid information in the diagnosis of neonatal sepsis

1, 2 / Wolfgang Erwa3 / Kurt R. Herkner4 / David C. Kasper4 / Wilhelm Müller2 / Bernhard Resch1

1Research Unit for Neonatal Infectious Diseases and Epidemiology, Medical University of Graz, Graz, Austria

2Division of Neonatology, Department of Pediatrics, Medical University of Graz, Graz, Austria

3Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria

4Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

Corresponding author: Dr. Christina Cimenti, Department of Pediatrics, Medical University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria Phone: +43 316 38512605, Fax: +43 316 38512619

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 50, Issue 8, Pages 1429–1432, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/cclm-2011-0656, February 2012

Publication History

Received:
2011-09-13
Accepted:
2012-02-06
Published Online:
2012-02-23

Abstract

Background: To determine the predictive value of the immature granulocyte count and the immature myeloid information in neonatal early onset sepsis we examined 133 blood samples of patients admitted to our neonatal intensive care unit.

Methods: Measurements were performed using the Sysmex XE-2100, an automated hematological analyzer. Patients were divided into two groups: 1) symptomatic neonates with diagnosis of early onset sepsis; and 2) controls including asymptomatic neonates who were admitted because of prematurity, low birth weight, or delayed postnatal transition.

Results: The number of immature granulocytes and the immature myeloid information were significantly elevated in neonates with early onset sepsis compared to controls (median 280/μL vs. 50/μL, p=0.049 and 639/μL vs. 89/μL, p<0.0001, respectively).

Conclusions: Automated determinations of immature granulocytes and immature myeloid information seem to be useful adjunctive methods in the diagnosis of neonatal early onset sepsis.

Keywords: immature granulocytes; immature myeloid information; neonatal sepsis

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