Jump to ContentJump to Main Navigation

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

12 Issues per year


IMPACT FACTOR 2014: 2.707
Rank 6 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 0.741
Source Normalized Impact per Paper (SNIP) 2014: 1.011
Impact per Publication (IPP) 2014: 2.310

VolumeIssuePage

Issues

Neurophil gelatinase-associated lipocalin as a new biomarker in laboratory medicine

Konstantinos Makris1 / Demetrios Rizos2 / Nikolaos Kafkas3 / 4

1Clinical Biochemistry Department, KAT General Hospital, Kifissia, Greece

2Hormone Laboratory, 2nd Department of Obstetrics and Gynecology, Medical School, University of Athens, “Aretaieio” Hospital, Athens, Greece

3Cardiology Department, KAT General Hospital, Kifissia, Greece

4Central Laboratories, Diamedica S.A., Athens, Greece

Corresponding author: Dr. Alexander Haliassos, Central Laboratories, Diamedica S.A., 1 Xenias Street, 115 27, Athens, Greece Phone: +30 694 4373473

Citation Information: Clinical Chemistry and Laboratory Medicine (CCLM). Volume 50, Issue 9, Pages 1519–1532, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/cclm-2012-0227, July 2012

Publication History

Received:
2012-04-09
Accepted:
2012-05-29
Published Online:
2012-07-09

Abstract

Neutrophil gelatinase-associated lipocalin (NGAL) is a 25 kDa protein of the lipocalin superfamily. This protein is expressed and secreted by immune cells, hepatocytes, and renal tubular cells in various pathologic states. NGAL has recently generated great interest as an early biomarker of renal injury. However, like many other endogenous biomarkers it is not produced by just one cell type and it exists in more than one molecular form. As recent research has shown different pathological conditions may involved in the production of this molecule. This review summarizes the current knowledge about the biology of NGAL and examines the role of this molecule of acute renal injury as well as in other pathologic conditions like neoplasia, anemia, pregnancy, cardiovascular disease chronic kidney disease and in cardiorenal syndrome. Commercial and research immunoassays are used to measure NGAL in both plasma and urine but these assays are not standardized. The existence of different molecular forms of NGAL and their expression at various disease states further complicates the interpretation of the results. Pre analytical issues and biological variation are also not fully elucidated.

Keywords: biomarkers; kidney injury; lipocalin 2; neutrophil gelatinase-associated lipocalin (NGAL); siderocalin

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
[2]
Tahereh Ebrahimi, Hamid Pirasteh, Bijan Rezakhaniha, Banafshe Dormanesh, Rahman Ghaffarzadegan Rabati, Emad Yahaghi, and Aram Mokarizadeh
Tumor Biology, 2015
[3]
Yesim Bayoglu Tekin, Emine Seda Guvendag Guven, Ulku Mete Ural, Zihni Acar Yazici, Aynur Kirbas, and Figen Kir Sahin
The Journal of Maternal-Fetal & Neonatal Medicine, 2015, Page 1
[4]
Nadia Rucci, Mattia Capulli, Sara Gemini Piperni, Alfredo Cappariello, Patrick Lau, Petra Frings-Meuthen, Martina Heer, and Anna Teti
Journal of Bone and Mineral Research, 2015, Volume 30, Number 2, Page 357
[5]
Jörg Stypmann, Manfred Fobker, Katharina Rosing, Markus Engelen, Stefan Gunia, Angelo Maria Dell’Aquila, and Jerzy-Roch Nofer
Journal of Cardiology, 2015
[6]
Peter A. McCullough and John L. Jefferies
The American Journal of Medicine, 2015, Volume 128, Number 3, Page 312.e1
[7]
Grigorios Karampas, Makarios Eleftheriades, Konstantinos Panoulis, Myrto Rizou, Alexander Haliassos, Demetrios Hassiakos, Nikolaos Vitoratos, and Demetrios Rizos
Prenatal Diagnosis, 2014, Volume 34, Number 8, Page 726
[8]
Midori Hasegawa, Junichi Ishii, Fumihiko Kitagawa, Kazuo Takahashi, Hiroki Hayashi, Shigehisa Koide, Makoto Tomita, Hiroshi Takahashi, Yukio Ozaki, and Yukio Yuzawa
Heart and Vessels, 2015, Volume 30, Number 1, Page 81
[9]
Giuseppe Lippi, Alberta Caleffi, Silvia Pipitone, Gianfranco Elia, Anna Ngah, Rosalia Aloe, Paola Avanzini, and Carlo Ferrari
Clinica Chimica Acta, 2013, Volume 418, Page 59

Comments (0)

Please log in or register to comment.