Trace elements and bone health : Clinical Chemistry and Laboratory Medicine uses cookies, tags, and tracking settings to store information that help give you the very best browsing experience.
To understand more about cookies, tags, and tracking, see our Privacy Statement
I accept all cookies for the De Gruyter Online site

Jump to ContentJump to Main Navigation

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

IMPACT FACTOR 2014: 2.707
Rank 6 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2014: 0.741
Source Normalized Impact per Paper (SNIP) 2014: 1.011
Impact per Publication (IPP) 2014: 2.310



30,00 € / $42.00 / £23.00

Get Access to Full Text

Trace elements and bone health

1 / Petra Nemcikova2 / Petr Matucha1

1Institute of Endocrinology, Prague, Czech Republic

2Department of Internal Medicine, Hospital of Jindrichuv Hradec, Jindrichuv Hradec, Czech Republic

Corresponding author: Prof. MUDr. Ivana Zofková, DrSc., Institute of Endocrinology, Narodni 8, 116 94 Prague 1, Czech Republic

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 51, Issue 8, Pages 1555–1561, ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/cclm-2012-0868, March 2013

Publication History

Published Online:


The importance of nutrition factors such as calcium, vitamin D and vitamin K for the integrity of the skeleton is well known. Moreover, bone health is positively influenced by certain elements (e.g., zinc, copper, fluorine, manganese, magnesium, iron and boron). Deficiency of these elements slows down the increase of bone mass in childhood and/or in adolescence and accelerates bone loss after menopause or in old age. Deterioration of bone quality increases the risk of fractures. Monitoring of homeostasis of the trace elements together with the measurement of bone density and biochemical markers of bone metabolism should be used to identify and treat patients at risk of non-traumatic fractures. Factors determining the effectivity of supplementation include dose, duration of treatment, serum concentrations, as well as interactions among individual elements. Here, we review the effect of the most important trace elements on the skeleton and evaluate their clinical importance.

Keywords: bone density; bone quality; cadmium; copper; magnesium; manganese; zinc

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Xiaoman Luo, Davide Barbieri, Noel Davison, Yonggang Yan, Joost D. de Bruijn, and Huipin Yuan
Acta Biomaterialia, 2014, Volume 10, Number 1, Page 477
Binxiu Zhao, Kunzheng Wang, Jiexiu Zhao, and Yufeng Luo
Biological Trace Element Research, 2013, Volume 154, Number 3, Page 333

Comments (0)

Please log in or register to comment.