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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Editorial Board Member: Gillery, Philippe / Kazmierczak, Steven / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Whitfield, John B.

12 Issues per year

IMPACT FACTOR 2013: 2.955
Rank 5 out of 29 in category Medical Laboratory Technology in the 2013 Thomson Reuters Journal Citation Report/Science Edition



Volume 52, Issue 11 (Nov 2014)


Page i

Published Online: 09/30/2014


From symptoms to biomarkers: a change of paradigm

Plebani, Mario

Page 1513

Published Online: 09/30/2014


Biochemical markers in early diagnosis and management of systemic amyloidoses

Lavatelli, Francesca / Albertini, Riccardo / Di Fonzo, Andrea / Palladini, Giovanni / Merlini, Giampaolo

Page 1517

Published Online: 05/28/2014

The accuracy of the anti-mitochondrial antibody and the M2 subtype test for diagnosis of primary biliary cirrhosis: a meta-analysis

Hu, Shiling / Zhao, Fengrong / Wang, Qingsong / Chen, Wei-Xian

Page 1533

Published Online: 02/06/2014

Genetics and Molecular Diagnostics

Selection of an optimal method for co-isolation of circulating DNA and miRNA from the plasma of pregnant women

Sedlackova, Tatiana / Repiska, Gabriela / Minarik, Gabriel

Page 1543

Published Online: 05/09/2014

General Clinical Chemistry and Laboratory Medicine

Harmonisation of seven common enzyme results through EQA

Weykamp, Cas / Franck, Paul / Gunnewiek, Jacqueline Klein / de Jonge, Robert / Kuypers, Aldy / van Loon, Douwe / Steigstra, Herman / Cobbaert, Christa

Page 1549

Published Online: 05/29/2014

Harmonization in hemolysis detection and prevention. A working group of the Catalonian Health Institute (ICS) experience

Fernandez, Pilar / Llopis, María Antonia / Perich, Carmen / Alsina, Maria Jesús / Alvarez, Virtudes / Biosca, Carmen / Busquets, Gloria / Domenech, Maria Vicenta / Gómez, Rubén / Llovet, Isabel / Minchinela, Joana / Pastor, Rosa / Ruiz, Rosa / Tarrés, Ester / Ibarz, Mercè / Simón, Margarita / Montesinos, Mercè

Page 1557

Published Online: 06/04/2014

Adopting European Network for Health Technology Assessments (EunetHTA) core model for diagnostic technologies for improving the accuracy and appropriateness of blood gas analyzers’ assessment

Franchin, Tiziana / Faggiano, Francesco / Plebani, Mario / Muraca, Maurizio / De Vivo, Liliana / Derrico, Pietro / Ritrovato, Matteo

Page 1569

Published Online: 05/15/2014

Impact of assay design on test performance: lessons learned from 25-hydroxyvitamin D

Farrell, Christopher-John L. / Soldo, Joshua / McWhinney, Brett / Bandodkar, Sushil / Herrmann, Markus

Page 1579

Published Online: 05/29/2014

Anti-ruthenium antibodies mimic macro-TSH in electrochemiluminescent immunoassay

Gessl, Alois / Blueml, Stefan / Bieglmayer, Christian / Marculescu, Rodrig

Page 1589

Published Online: 05/15/2014

The relationship between the Spine Deformity Index, biochemical parameters of bone metabolism and vascular calcifications: results from the Epidemiological VERtebral FRACtures iTalian Study (EVERFRACT) in dialysis patients

Fusaro, Maria / Gallieni, Maurizio / Noale, Marianna / Tripepi, Giovanni / Miozzo, Davide / Plebani, Mario / Zaninotto, Martina / Guglielmi, Giuseppe / Miotto, Diego / Fabris, Fabrizio / Piccoli, Antonio / Vilei, Maria Teresa / Sella, Stefania / Morachiello, Paolo / Stoppa, Fabrizio / Rossini, Maurizio / Giannini, Sandro

Page 1595

Published Online: 06/04/2014

Quantification of polyclonal free light chains in clinical samples using a single turbidimetric immunoassay

Faint, Jeffrey M. / Basu, Supratik / Sutton, David / Showell, Paul J. / Kalra, Philip A. / Gunson, Bridget K. / Jackson, Colette E. / Mushtaq, Adeel / Assi, Lakhvir K. / Carr-Smith, Hugh D. / Cockwell, Paul / Harding, Stephen J.

Page 1605

Published Online: 06/13/2014

Reference Values and Biological Variations

The importance of individual biology in the clinical use of serum biomarkers for ovarian cancer

Braga, Federica / Ferraro, Simona / Mozzi, Roberta / Panteghini, Mauro

Page 1625

Published Online: 05/15/2014

Cancer Diagnostics

Serum human epididymis protein 4 (HE4) as a tumor marker in men with lung cancer

Nagy, Béla / Bhattoa, Harjit Pal / Steiber, Zoltán / Csobán, Mária / Szilasi, Mária / Méhes, Gábor / Müller, Mónika / Lázár, József / Kappelmayer, János / Antal-Szalmás, Péter

Page 1639

Published Online: 05/15/2014

Intestinal permeability in patients with metastatic colon cancer treated with patupilone

Melichar, Bohuslav / Hyšpler, Radomír / Tichá, Alena / Kalábová, Hana / Vitásková, Denisa / Zezulová, Michaela / Dvořák, Josef / Cerman, Jaroslav / Doležel, Martin

Page 1649

Published Online: 06/17/2014

Cardiovascular Diseases

European multicenter analytical evaluation of the Abbott ARCHITECT STAT high sensitive troponin I immunoassay

Krintus, Magdalena / Kozinski, Marek / Boudry, Pascal / Capell, Nuria Estañ / Köller, Ursula / Lackner, Karl / Lefèvre, Guillaume / Lennartz, Lieselotte / Lotz, Johannes / Herranz, Antonio Mora / Nybo, Mads / Plebani, Mario / Sandberg, Maria B. / Schratzberger, Wolfgang / Shih, Jessie / Skadberg, Øyvind / Chargui, Ahmed Taoufik / Zaninotto, Martina / Sypniewska, Grazyna

Page 1657

Published Online: 06/04/2014

Infectious Diseases

Early indicators of severity and construction of a risk model for prognosis based upon laboratory parameters in patients with hemorrhagic fever with renal syndrome

Du, Hong / Li, Jing / Yu, Hai-Tao / Jiang, Wei / Zhang, Ye / Wang, Jun-Ning / Wang, Ping-Zhong / Bai, Xue-Fan

Page 1667

Published Online: 06/04/2014


Automated indirect immunofluorescence antinuclear antibody analysis is a standardized alternative for visual microscope interpretation

Bonroy, Carolien / Verfaillie, Charlotte / Smith, Vanessa / Persijn, Lies / De Witte, Evy / De Keyser, Filip / Devreese, Katrien

Page 1677

Published Online: 09/30/2014

Letters to the Editor

The future of the laboratory information system – what are the requirements for a powerful system for a laboratory data management?

Kammergruber, Roland / Robold, Stephanie / Karliç, Jasna / Durner, Jürgen

Page e225

Published Online: 06/04/2014

Hypernatraemia in disguise

Joosen, Annemiek M.C.P. / Boonen, Kristel / Hulsman, Niels / Schuitemaker, Frits J. / Thelen, Marc H.M.

Page e231

Published Online: 06/04/2014

Interference of therapeutic monoclonal immunoglobulins in the investigation of M-proteins

Ruinemans-Koerts, Janneke / Verkroost, Cyriel / Schmidt-Hieltjes, Yvonne / Wiegers, Cees / Curvers, Joyce / Thelen, Marc / van Luin, Matthijs

Page e235

Published Online: 05/08/2014

The impact of exercise on the variation of serum free light chains

Jacobs, Joannes F.M. / Eijsvogels, Thijs M.H. / van der Geest, Kornelis S.M. / Koenen, Hans J.P.M. / Hutchison, Colin A. / Boots, Annemieke M.H. / Hopman, Maria T.E. / Joosten, Irma

Page e239

Published Online: 05/06/2014

Response to Jacobs: N Latex FLC serum free light-chain assays in patients with renal impairment

Berlanga, Oscar / Carr-Smith, Hugh / Harding, Stephen

Page e243

Published Online: 06/25/2014

Reply to Berlanga et al. (DOI 10.1515/cclm-2014-0420)

Jacobs, Joannes F.M. / Hoedemakers, Rein M.J. / te Velthuis, Henk

Page e247

Published Online: 08/12/2014

Mean platelet volume in patients with non-alcoholic fatty liver disease: is mean platelet volume ready as a surrogate marker?

Kocabay, Gonenc / Karabay, Can Yucel / Kalayci, Arzu / Colak, Yasar

Page e249

Published Online: 05/21/2014

False-positive D-dimer result in a latex-enhanced immunoassay caused by interfering human anti-mouse antibodies

Robier, Christoph / Edler, Eva / Klescher, Daniela / Neubauer, Manfred

Page e253

Published Online: 06/04/2014

D-Dimer in normal pregnancy: determination of reference values for three commercially available assays

Bergmann, Frauke / Pingel, Nadine / Czwalinna, Andreas / Koch, Matthias

Page e257

Published Online: 05/07/2014

Paraoxonase 2 sequence variation (c.311 C>G) is associated with a modest decrease in circulating LDL size in children and adolescents

Lochard, Nadheige / Levy, Emile / Lambert, Marie / Paradis, Gilles / O’Loughlin, Jennifer / Henderson, Mélanie / Delvin, Edgard E.

Page e261

Published Online: 05/07/2014

The effect of volume of hydrochloric acid preservation on 24-hour urinary catecholamine test

Li, Ming / Zhang, Qian / Hu, Yingying / Yang, Guohua / Song, Ailing

Page e265

Published Online: 05/15/2014

Congress Abstracts

The 3rd EFLM-UEMS Congress

Page eA205

Published Online: 09/20/2014

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