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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Schlattmann, Peter / Tate, Jillian R. / Tsongalis, Gregory J.

12 Issues per year

IMPACT FACTOR 2014: 2.707
Rank 6 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR): 0.860
Source Normalized Impact per Paper (SNIP): 1.046



Volume 53, Issue 8 (Jul 2015)


Page i

Published Online: 06/20/2015


Once upon a time: a tale of ISO 15189 accreditation

Plebani, Mario / Sciacovelli, Laura / Chiozza, Maria Laura / Panteghini, Mauro

Page 1127

Published Online: 05/20/2015

A new integrated tool for assessing and monitoring test comparability and stability

Secchiero, Sandra / Plebani, Mario

Page 1131

Published Online: 02/11/2015

Liver-FibroSTARD checklist and glossary: tools for standardized design and reporting of diagnostic accuracy studies of liver fibrosis tests

Guéchot, Jérôme / Boursier, Jérôme / de Ledinghen, Victor / Poynard, Thierry / Carrat, Fabrice / Leroy, Vincent / Wong, Grace Lai-Hung / Friedrich-Rust, Mireen / Fraquelli, Mirella / Plebani, Mario / Sebastiani, Giada / Myers, Robert / Angulo, Paul / Bertrais, Sandrine / Wendum, Dominique / Bricault, Ivan / Calès, Paul / from the ARDENT group and/or AFEFª

Page 1135

Published Online: 04/03/2015


Thromboembolic risk in hematological malignancies

Franchini, Massimo

Page 1139

Published Online: 12/11/2014

A review of the cut-off points for the diagnosis of vitamin B12 deficiency in the general population

Aparicio-Ugarriza, Raquel / Palacios, Gonzalo / Alder, Monika / González-Gross, Marcela

Page 1149

Published Online: 12/03/2014

Opinion Paper

Permissible limits for uncertainty of measurement in laboratory medicine

Haeckel, Rainer / Wosniok, Werner / Gurr, Ebrhard / Peil, Burkhard

Page 1161

Published Online: 01/23/2015

EFLM Position Paper

Flexible scope for ISO 15189 accreditation: a guidance prepared by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group Accreditation and ISO/CEN standards (WG-A/ISO)

Thelen, Marc H.M. / Vanstapel, Florent J.L.A. / Kroupis, Christos / Vukasovic, Ines / Boursier, Guilaime / Barrett, Edward / Andreu, Francisco Bernabeu / Brguljan, Pika Meško / Brugnoni, Duilio / Lohmander, Maria / Sprongl, Ludek / Vodnik, Tatjana / Ghita, Irina / Vaubourdolle, Michel / Huisman, Willem / on behalf of the Working Group Accreditation ISO/CEN standards (WG-A/ISO) of the EFLM

Page 1173

Published Online: 06/06/2015

Genetics and Molecular Diagnostics

Evaluation of a low-cost procedure for sampling, long-term storage, and extraction of RNA from blood for qPCR analyses

Mærkedahl, Rasmus B. / Frøkiær, Hanne / Lauritzen, Lotte / Metzdorff, Stine B.

Page 1181

Published Online: 01/20/2015

Application of real-time PCR of sex-independent insertion-deletion polymorphisms to determine fetal sex using cell-free fetal DNA from maternal plasma

Yee Ho, Sherry Sze / Barrett, Angela / Thadani, Henna / Asibal, Cecille Laureano / Koay, Evelyn Siew-Chuan / Choolani, Mahesh

Page 1189

Published Online: 01/10/2015

General Clinical Chemistry and Laboratory Medicine

The Empower project – a new way of assessing and monitoring test comparability and stability

De Grande, Linde A.C. / Goossens, Kenneth / Van Uytfanghe, Katleen / Stöckl, Dietmar / Thienpont, Linda M.

Page 1197

Published Online: 01/15/2015

Comparison of four automated serum vitamin B12 assays

İspir, Emre / Serdar, Muhittin A. / Ozgurtas, Taner / Gulbahar, Ozlem / Akın, Kadir Okhan / Yesildal, Fatih / Kurt, İsmail

Page 1205

Published Online: 01/20/2015

Combined indicator of vitamin B12 status: modification for missing biomarkers and folate status and recommendations for revised cut-points

Fedosov, Sergey N. / Brito, Alex / Miller, Joshua W. / Green, Ralph / Allen, Lindsay H.

Page 1215

Published Online: 01/14/2015

INR vs. thrombin generation assays for guiding VKA reversal: a retrospective comparison

Herpers, Robert / van Rossum, André P. / van Beem, Rachel T. / Michel, W. Margot / Strijbis, Viola J.F. / Strengers, Paul F.W. / Castel, Ad / Brinkman, Herm Jan M.

Page 1227

Published Online: 01/20/2015

Determination of dabigatran in plasma, serum, and urine samples: comparison of six methods

Du, Shanshan / Weiss, Christel / Christina, Giese / Krämer, Sandra / Wehling, Martin / Krämer, Roland / Harenberg, Job

Page 1237

Published Online: 01/23/2015

Simple high-throughput analytical method using ultra-performance liquid chromatography coupled with tandem mass spectrometry to quantify total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in urine

Yang, Jun-Young / Ahn, Hyun-Kyong / Lee, Si-Won / Han, You-Jung / Oh, Young-Jun / Velázquez-Armenta, E. Yadira / Nava-Ocampo, Alejandro A.

Page 1249

Published Online: 01/23/2015

Revival of physostigmine – a novel HPLC assay for simultaneous determination of physostigmine and its metabolite eseroline designed for a pharmacokinetic study of septic patients

Pinder, Nadine / Zimmermann, Johannes B. / Hofer, Stefan / Brenner, Thorsten / Weigand, Markus A. / Gubbe, Ute / Hoppe-Tichy, Torsten / Swoboda, Stefanie

Page 1259

Published Online: 01/07/2015

Relationship between antiphosphatidylserine/prothrombin and conventional antiphospholipid antibodies in primary antiphospholipid syndrome

Hoxha, Ariela / Ruffatti, Amelia / Mattia, Elena / Meneghel, Lauro / Tonello, Marta / Salvan, Elisa / Pengo, Vittorio / Punzi, Leonardo

Page 1265

Published Online: 01/06/2015

Reference Values and Biological Variations

Relevance of EDTA carryover during blood collection

Cadamuro, Janne / Felder, Thomas Klaus / Oberkofler, Hannes / Mrazek, Cornelia / Wiedemann, Helmut / Haschke-Becher, Elisabeth

Page 1271

Published Online: 01/23/2015

Reference intervals for renal injury biomarkers neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 in young infants

Zwiers, Alexandra J.M. / de Wildt, Saskia N. / de Rijke, Yolanda B. / Willemsen, Sten P. / Abdullahi, Najma S. / Tibboel, Dick / Cransberg, Karlien

Page 1279

Published Online: 02/07/2015

Cardiovascular Diseases

Letters to the Editors

Analytical challenges related to the use of biomarker ratios for the biological diagnosis of Alzheimer’s disease

Lehmann, Sylvain / Delaby, Constance / Paquet, Claire / Gabelle, Audrey

Page e175

Published Online: 04/14/2015

Serum brain injury biomarkers as predictors of mortality after severe aneurysmal subarachnoid hemorrhage: preliminary results

de Azúa López, Zaida Ruiz / Egea-Guerrero, Juan José / Rivera-Rubiales, Gloria / Rodríguez-Rodríguez, Ana / Vilches-Arenas, Ángel / Murillo-Cabezas, Francisco

Page e179

Published Online: 03/10/2015

Tumor markers assay by the Lumipulse G

Cosma, Chiara / Faggian, Diego / Giunta, Chiara / Plebani, Mario

Page e183

Published Online: 03/21/2015

Real-world costs of laboratory tests for non-small cell lung cancer

van der Linden, Naomi / Smit, Egbert F. / Uyl-de Groot, Carin A.

Page e187

Published Online: 03/12/2015

Impact of stopping vitamin K antagonist therapy on concentrations of dephospho-uncarboxylated Matrix Gla protein

Delanaye, Pierre / Dubois, Bernard E. / Lukas, Pierre / Peters, Pierre / Krzesinski, Jean-Marie / Pottel, Hans / Cavalier, Etienne

Page e191

Published Online: 03/09/2015

Practicability of fetal scalp blood sampling during labor using microtubes and a point-of-care (POC) lactate testing device: difficulty assessment, sampling time and failure rates

Reif, Philipp / Ulrich, Daniela / Lakovschek, Ioana / Tappauf, Carmen / Lang, Uwe / Schöll, Wolfgang

Page e195

Published Online: 03/14/2015

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