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ZnO nanoparticles in the synthesis of AB ring core of camptothecin

1Organic & Medicinal Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, India

Citation Information: Chemical Papers. Volume 64, Issue 6, Pages 812–817, ISSN (Online) 1336-9075, DOI: 10.2478/s11696-010-0058-y, September 2010

Publication History

Published Online:
2010-09-23

Abstract

For the first time, synthesis of AB ring core of camptothecin synthons such as (2-chloroquinolin-3-yl)methanols (Va-Vg) using zinc oxide nanoparticles is reported. The desired attractive products were obtained in high yields, short reaction time, using a simple work-up procedure with the purification of products by non-chromatographic methods.

Keywords: ZnO nanoparticles; camptothecin synthons; (2-chloroquinolin-3-yl)methanol

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