The industrial production of refined sodium bicarbonate is realized in large-scale bubble columns, called the BIR columns. Several complex phenomena exist in these columns, such as three-phase flow, gas-liquid mass transfer of CO2, and crystallization. This work deals with the development of an operational BIR column model using the compartmental modeling approach. It is fed by previous works and current studies. A parametric sensitivity analysis is realized to identify the more important modeling parameters and to point the future research that have to be performed. Some simulations results are presented for typical operating conditions of an industrial column.