Jump to ContentJump to Main Navigation
Show Summary Details

Drug Metabolism and Personalized Therapy

Official journal of the European Society of Pharmacogenomics and Personalised Therapy

Editor-in-Chief: Llerena, Adrián

Editorial Board Member: Benjeddou, Mongi / Chen, Bing / Dahl, Marja-Liisa / Devinsky, Ferdinand / Hirata, Rosario D. C. / Hubacek, Jaroslav A. / Ingelman-Sundberg, Magnus / Maitland-van der Zee, Anke-Hilse / Manolopoulos, Vangelis G. / Marc, Janja / Melichar, Bohuslav / Meyer, Urs A. / Nair, Sujit / Nofziger, Charity / Peiro, Ana / Sadee, Wolfgang / Salazar, Luis A. / Simmaco, Maurizio / Turpeinen, Miia / Schaik, Ron / Shin, Jae-Gook / Visvikis-Siest, Sophie / Zanger, Ulrich M.


SCImago Journal Rank (SJR) 2015: 0.447
Source Normalized Impact per Paper (SNIP) 2015: 0.524
Impact per Publication (IPP) 2015: 1.329

99,00 € / $149.00 / £75.00*

Online
ISSN
2363-8915
See all formats and pricing



Select Volume and Issue
Loading journal volume and issue information...

P-Glycoprotein- and cytochrome P-450-mediated herbal drug interactions

Yamsani Shravan Kumar1 / Devandla Adukondalu1 / Dharani Sathish1 / Yamsani Vamshi Vishnu1 / Gannu Ramesh1 / Athukuri Bharagavi Latha1 / Palem Chinna Reddy1 / Manda Sarangapani1 / 1

1Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, AP, India

Corresponding author: Y. Madhusudan Rao, Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009, AP, India Phone: +91-870-3091323, Fax: +91-870-2453508

Citation Information: Drug Metabolism and Drug Interactions. Volume 25, Issue 1-4, Pages 3–16, ISSN (Online) 2191-0162, ISSN (Print) 0792-5077, DOI: 10.1515/DMDI.2010.006, January 2011

Publication History

Received:
2010-08-01
Accepted:
2010-12-01
Published Online:
2011-01-02

Abstract

P-Glycoprotein (P-gp), the most extensively studied ATP-binding cassette transporter, functions as a biological barrier by extruding toxic substances and xenobiotics out of cells. Drug efflux pumps such as P-gp play a functional role in determining the pharmacokinetics of drugs administered by oral and parenteral routes. Determining the activity of drug efflux transport proteins has important implications in the identification of substrates and/or inhibitors. The significant role of the small intestine in reducing the oral bioavailability of drugs is due to metabolic enzymes and efflux transporters. The role of cytochrome P-450 3A (CYP3A) and P-gp in intestinal drug disposition has been highlighted. This review examines the structure, localisation and functional role of P-gp, the mechanism of drug efflux and drug-herb interactions.

Keywords: cytochrome P-450 3A; inhibitors; in vitro; in vivo; P-glycoprotein

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Tadatoshi Tanino, Noriaki Nagai, and Yoshinori Funakami
Journal of Pharmacy and Pharmacology, 2015, Page n/a
[2]
M. Spanakis, I.S. Vizirianakis, G. Batzias, and I. Niopas
Pharmacology, 2013, Volume 91, Number 1-2, Page 112
[3]
Bei Tong, Yannong Dou, Ting Wang, Juntao Yu, Xin Wu, Qian Lu, Guixin Chou, Zhengtao Wang, Lingyi Kong, Yue Dai, and Yufeng Xia
Toxicology and Applied Pharmacology, 2015, Volume 282, Number 1, Page 90
[4]
Yuhua Li, Ling Huang, Xuezhen Zeng, Guoping Zhong, Mengjia Ying, Min Huang, and Huichang Bi
Chemico-Biological Interactions, 2014, Volume 213, Page 44
[5]
Yu-hua Li, Hui-chang Bi, Ling Huang, Jing Jin, Guo-ping Zhong, Xu-nian Zhou, and Min Huang
Acta Pharmacologica Sinica, 2014, Volume 35, Number 2, Page 283
[6]
Hui Li, Hong Wu, Chen Shen, Jin-Yun Chen, Shun-Li Hu, and Huan Wu
Basic & Clinical Pharmacology & Toxicology, 2013, Page n/a
[7]
Miao Hu, Lan Fan, Hong-Hao Zhou, and Brian Tomlinson
Expert Review of Molecular Diagnostics, 2012, Volume 12, Number 8, Page 815
[8]
Enoche F. Oga, Shuichi Sekine, Yoshihisa Shitara, and Toshiharu Horie
Journal of Ethnopharmacology, 2012, Volume 144, Number 3, Page 612
[9]
Hyo-Kyung Han
Archives of Pharmacal Research, 2011, Volume 34, Number 11, Page 1865

Comments (0)

Please log in or register to comment.