Drug Metabolism and Personalized Therapy
Official journal of the European Society of Pharmacogenomics and Personalised Therapy
Editor-in-Chief: Llerena, Adrián
Editorial Board Member: Benjeddou, Mongi / Chen, Bing / Dahl, Marja-Liisa / Devinsky, Ferdinand / Hirata, Rosario D. C. / Hubacek, Jaroslav A. / Ingelman-Sundberg, Magnus / Maitland-van de Zee, Anke-Hilse / Manolopoulos, Vangelis G. / Marc, Janja / Melichar, Bohuslav / Meyer, Urs A. / Nair, Sujit / Nofziger, Charity / Peiro, Ana / Sadee, Wolfgang / Salazar, Luis A. / Simmaco, Maurizio / Turpeinen, Miia / Schaik, Ron / Shin, Jae-Gook / Siest, Gérard / Visvikis-Siest, Sophie / Zanger, Ulrich M.
SCImago Journal Rank (SJR) 2015: 0.447
Source Normalized Impact per Paper (SNIP) 2015: 0.524
Impact per Publication (IPP) 2015: 1.329
Quantitative structure-activity relationship analysis of thiazolidineones: potent antidiabetic compounds
1Department of Applied Chemistry, BBA University, Lucknow, Uttar Pradesh, India
2A.R.S.D. College, University of Delhi, New Delhi, India
3Department of Chemistry, MNNIT Allahabad, Uttar Pradesh, India
4ACBR, University of Delhi, New Delhi, India
Citation Information: Drug Metabolism and Drug Interactions. Volume 28, Issue 1, Pages 31–47, ISSN (Online) 2191-0162, ISSN (Print) 0792-5077, DOI: 10.1515/dmdi-2012-0036, February 2013
- Published Online:
Background: Type 2 diabetes is the most common form of diabetes, accounting for over 90% of cases. Current treatment approaches for type 2 diabetes include diet, exercise, and a variety of pharmacologic agents, including insulin, biguanides, sulfonylureas, and thiazolidinediones.
Methods: In the present scenario, researchers focused themselves on thiazolidine ring-based compounds to cure type 2 diabetes mellitus. Among the peroxisome proliferator activated receptor (PPAR) family, PPAR-γ is the most effective in curing glucose homeostasis.
Results and conclusions: Thiazolidine ring-based compounds act as PPAR-γ agonists, and herein, we have successfully developed nine derivatives of thiazolidine ring-based compounds that are found to be biologically potent using two-dimensional quantitative structure-activity relationship model.