Hormone Molecular Biology and Clinical Investigation
Editor-in-Chief: Pasqualini, Jorge R.
Editorial Board Member: Fujimoto, Jiro / Hubalek, Michael / Morfin, Robert / Saad, Farid / Schally, Andrew V. / Alexis, Michael N. / Baniahmad, Aria / Beato, Miguel / Bouillon, Roger / Bouvier, Michel / Brodie, Angela / Campagnoli, Carlo / Carruba, Giuseppe / Catt, FRACP, Kevin J. / Chen, Shiuan / Chetrite, Gerard / Cidlowski, John A. / Clarke, Robert / Coelingh Bennink, Herjan J.T. / Danza, Giovanna / Darbre, Philippa D. / Daxenbichler, Günter / Kloet, Ronald / Nicola, Alejandro F. / Drouin, Jacques / Dufau, Maria L. / Edwards, Dean P. / Evans, Dean / Falany, Charles N. / Fernandez-Perez, Leandro / Ferroud, Clotilde / Flores-Morales, Amilcar / Garcia-Segura, Luis M. / Gee, J.M.W. / Genazzani, Andrea R. / Greene, Geoffrey L. / Groner, Bernd / Hilakivi-Clarke, Leena / Hampl, Richard / Iwase, Hirotaka / Jordan, V.Craig / Klocker, Helmut / Kurebayashi, Jyunichi / Labrie, Fernand / Lee, Adrian V. / Libertun, Carlos / Luu-The, Van / Mendelson, Carole R. / Mück, Alfred O. / Murphy, Leigh C. / Muti, Paola / Nicholson, Robert / Norman, Anthony W. / O'Malley, Bert W. / Rafestin-Oblin, Marie-Edith / Raynaud, Jean-Pierre / Renoir, Michel / Sanchez, Edwin R. / Schindler, Adolf E. / Senn, Hans-Jörg / Söderqvist, Gunnar / Speirs, Valerie / Stanczyk, Frank Z. / Starka, Luboslav / Sutherland, Robert / Sutter, Thomas R. / Traish, Adbulmaged / Verhoeven, Guido / Wahli, Walter / Wildt, Ludwig / Yang, Kaiping / Ylikomi, Timo
12 Issues per year
Volume 18 (2014)
Volume 17 (2014)
Volume 16 (2013)
Volume 15 (2013)
Volume 14 (2013)
Volume 13 (2013)
Volume 12 (2012)
Volume 11 (2012)
Volume 10 (2012)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2011)
Volume 6 (2011)
Volume 5 (2011)
Volume 3 (2010)
Volume 4 (2010)
Volume 2 (2010)
Most Downloaded Articles
- Natural products and the aging process by Ergin, Volkan/ Bali, Elif Burcu/ Hariry, Reza Ebrahimi and Karasu, Çimen
- Enhanced Na+, K+-ATPase activity and endothelial modulation decrease phenylephrine-induced contraction in aorta from ouabain-treated normotensive and hypertensive rats by Davel, Ana Paula/ Couto, Gisele Kruger/ Wenceslau, Camilla Ferreira/ Peres, Emilia Cristina/ Xavier, Fabiano Elias and Rossoni, Luciana Venturini
The influence of low dose finasteride, a type II 5α-reductase inhibitor, on circulating neuroactive steroids
1Institute of Endocrinology, CZ 11694 Prague 1, Czech Republic
Citation Information: Hormone Molecular Biology and Clinical Investigation. Volume 1, Issue 2, Pages 95–102, ISSN (Online) 1868-1891, ISSN (Print) 1868-1883, DOI: 10.1515/HMBCI.2010.010, September 2009
- Published Online:
Background: Finasteride is a 5α-reductase inhibitor that has received clinical approval for the treatment of human benign prostatic hyperplasia and androgenetic alopecia. The treatment is practically without side effects, although some occasional cases of depression syndrome have been reported. 5α-Reductase is an enzyme responsible for the reduction of testosterone, progesterone or deoxycorticosterone to their 5α-reduced derivatives possessing anticonvulsant, antidepressant, and anxiolytic activity. Therefore, the formation of GABAergic neuroactive steroids is likely to be impacted by finasteride.
Objective: The objective of the study was to show how the treatment of premature androgenetic alopecia with low doses (1 mg/day) of finasteride influences the broad spectrum of steroids with potential neuroactivity.
Methods: A group of 12 men with premature androgenetic alopecia participated in the present study. The steroid hormone profile was determined for all individuals. Finasteride was administered for 4 months at a daily dose of 1 mg. After the treatment, the same hormonal profile was determined again.
Results: 5α-Reduced steroids, e.g., 5α-dihydrotestosterone, androsterone, epiandrosterone, 5α-androstene-3α,17β-diol, allopregnanolone, isopregnaolone, and some 5-ene steroids, such as dehydroepiandrosterone and pregnenolone, decreased gradually during treatment.
Conclusions: The decrease of 5α-reduced steroids, especially of allopregnanediol, dihydrotestosterone, and pregnenolone, is probably one of the factors responsible for the increased occurrence of depression in men treated with finasteride, even at low doses.