Volume 7 (2011)
Volume 5 (2009)
Volume 4 (2008)
Volume 3 (2007)
Volume 2 (2006)
Volume 1 (2005)
Most Downloaded Articles
- An Introduction to Causal Inference by Pearl, Judea
- Principal Stratification: A Broader Vision by Shrier, Ian/ Kaufman, Jay S./ Platt, Robert W. and Steele, Russell J.
- Sensitivity Analysis for Causal Inference under Unmeasured Confounding and Measurement Error Problems by Díaz, Iván and van der Laan, Mark J.
- Accuracy of Conventional and Marginal Structural Cox Model Estimators: A Simulation Study by Xiao, Yongling/ Abrahamowicz, Michal and Moodie, Erica E. M.
- Assessing the Causal Effect of Policies: An Example Using Stochastic Interventions by Díaz, Iván and van der Laan, Mark J.
Simple Optimal Weighting of Cases and Controls in Case-Control Studies
1University of California, Berkeley
2University of California, Berkeley
Citation Information: The International Journal of Biostatistics. Volume 4, Issue 1, ISSN (Online) 1557-4679, DOI: 10.2202/1557-4679.1115, September 2008
- Published Online:
Researchers of uncommon diseases are often interested in assessing potential risk factors. Given the low incidence of disease, these studies are frequently case-control in design. Such a design allows a sufficient number of cases to be obtained without extensive sampling and can increase efficiency; however, these case-control samples are then biased since the proportion of cases in the sample is not the same as the population of interest. Methods for analyzing case-control studies have focused on utilizing logistic regression models that provide conditional and not causal estimates of the odds ratio. This article will demonstrate the use of the prevalence probability and case-control weighted targeted maximum likelihood estimation (MLE), as described by van der Laan (2008), in order to obtain causal estimates of the parameters of interest (risk difference, relative risk, and odds ratio). It is meant to be used as a guide for researchers, with step-by-step directions to implement this methodology. We will also present simulation studies that show the improved efficiency of the case-control weighted targeted MLE compared to other techniques.
Keywords: case control sampling; causal effect; counterfactual; double robust estimation; estimating function; inverse probability of treatment weighting; locally efficient estimation; marginal structural models; targeted maximum likelihood estimation