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Publication Date:
March 2010
ISSN:
1557-4679
DOI:
10.2202/1557-4679.1223

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Ed. by Hubbard, Alan E. / van der Laan, Mark J.

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IMPACT FACTOR 2011: 1.284

A Pseudo-EM Algorithm for Clustering Incomplete Longitudinal Data

Mateen Shaikh / Paul D McNicholas / Anthony F Desmond

1University of Guelph

1University of Guelph

1University of Guelph

Citation Information: The International Journal of Biostatistics. Volume 6, Issue 1, Pages –, ISSN (Online) 1557-4679, DOI: 10.2202/1557-4679.1223, March 2010

Publication History:
Published Online:
2010-03-15

A method for clustering incomplete longitudinal data, and gene expression time course data in particular, is presented. Specifically, an existing method that utilizes mixtures of multivariate Gaussian distributions with modified Cholesky-decomposed covariance structure is extended to accommodate incomplete data. Parameter estimation is carried out in a fashion that is similar to an expectation-maximization algorithm. We focus on the particular application of clustering incomplete gene expression time course data. In this application, our approach gives good clustering performance when compared to the results when there is no missing data. Possible extensions of this work are also suggested.

Keywords: clustering; gene expression time course data; longitudinal data; missing data; mixture models; pseudo-EM

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