The International Journal of Biostatistics
Ed. by Chambaz, Antoine / Hubbard, Alan E. / van der Laan, Mark J.
2 Issues per year
IMPACT FACTOR 2014: 0.741
5-year IMPACT FACTOR: 1.475
SCImago Journal Rank (SJR) 2014: 1.247
Source Normalized Impact per Paper (SNIP) 2014: 1.078
Impact per Publication (IPP) 2014: 1.206
Mathematical Citation Quotient (MCQ) 2014: 0.07
Volume 11 (2015)
Volume 7 (2011)
Volume 5 (2009)
Volume 4 (2008)
Volume 3 (2007)
Volume 2 (2006)
Volume 1 (2005)
Most Downloaded Articles
- Sample Size Estimation for Repeated Measures Analysis in Randomized Clinical Trials with Missing Data by Lu, Kaifeng/ Luo, Xiaohui and Chen, Pei-Yun
- An Introduction to Causal Inference by Pearl, Judea
- Survival Models in Health Economic Evaluations: Balancing Fit and Parsimony to Improve Prediction by Jackson, Christopher H/ Sharples, Linda D and Thompson, Simon G
- Survival Curve Estimation with Dependent Left Truncated Data Using Cox's Model by Mackenzie, Todd
- Evaluating treatment effectiveness in patient subgroups: a comparison of propensity score methods with an automated matching approach by Radice, Rosalba/ Ramsahai, Roland/ Grieve, Richard/ Kreif, Noemi/ Sadique, Zia and Sekhon, Jasjeet S.
Clarifying the Role of Principal Stratification in the Paired Availability Design
1National Institutes of Health
2Johns Hopkins Medical Institutions
3National Institutes of Health
Citation Information: The International Journal of Biostatistics. Volume 7, Issue 1, Pages 1–11, ISSN (Online) 1557-4679, DOI: 10.2202/1557-4679.1338, May 2011
- Published Online:
The paired availability design for historical controls postulated four classes corresponding to the treatment (old or new) a participant would receive if arrival occurred during either of two time periods associated with different availabilities of treatment. These classes were later extended to other settings and called principal strata. Judea Pearl asks if principal stratification is a goal or a tool and lists four interpretations of principal stratification. In the case of the paired availability design, principal stratification is a tool that falls squarely into Pearl’s interpretation of principal stratification as “an approximation to research questions concerning population averages.” We describe the paired availability design and the important role played by principal stratification in estimating the effect of receipt of treatment in a population using data on changes in availability of treatment. We discuss the assumptions and their plausibility. We also introduce the extrapolated estimate to make the generalizability assumption more plausible. By showing why the assumptions are plausible we show why the paired availability design, which includes principal stratification as a key component, is useful for estimating the effect of receipt of treatment in a population. Thus, for our application, we answer Pearl’s challenge to clearly demonstrate the value of principal stratification.
Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.