Inhibitors of an angiotensin I-converting enzyme were produced from ?-zein in a batch reactor under subcritical and supercritical water conditions. Inhibitors produced under supercritical conditions in a flow reactor assembly were more sensitive. In a flow reactor system 5 mg of inhibitors were produced from 1 micromole of ?-zein. The hydrolysis products of ?-zein obtained in the flow reactor had a higher ACE inhibitory activity of 78% compared to 69% obtained using the batch reactor. An angiotensin I-converting enzyme [EC 3.4. 1 5. l] (ACE) is used to catalyze the production of vasoconstrictor angiotensin II and for the inactivation of the vasodilator bradykinin.
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Conversion of ?-Zein to an Angiotensin I-Converting Enzyme Inhibitor under the Supercritical Water Condition
1National Institute of Advanced Industrial Science and Technology (AIST), k-hatakeda@aist.go.jp
2National Institute of Advanced Industrial Science and Technology (AIST), s-maruyama@aist.go.jp
3National Institute of Advanced Industrial Science and Technology (AIST), suzuki-akira@aist.go.jp
4National Institute of Advanced Industrial Science and Technology (AIST), k.arai@aist.go.jp
Citation Information: International Journal of Chemical Reactor Engineering. Volume 6, Issue 1, Pages –, ISSN (Online) 1542-6580, DOI: 10.2202/1542-6580.1519, July 2008
Publication History:
- Published Online:
- 2008-07-24
Keywords: supercritical water; a-zein; angiotensin I-converting enzyme; inhibitor; protein
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