Solubility, which defines the liquid /solid equilibrium, is a key parameter to control a crystallization process. This work is focused on the effects of pH, temperature and impurities on the aqueous solubility of an Active Pharmaceutical Ingredient (API).As the API is a weak acid (pKa = 3.7), its solubility increases with the pH. On the basis of the experimental curve of solubility, a model was defined to fit the evolution of the solubility as a function of pH. In the case of this compound, studies revealed a weak influence of the temperature in comparison with the pH. So, the solubility of the compound is slightly impacted by the temperature.Some experiments were carried out in order to compare the solubility of the API, at the same pH and temperature, for different concentrations of impurities found in the process. The results revealed a solubility increase in presence of acetic acid and a high solubility decrease in presence of sodium chloride. By carrying out experiments on common ions salts, the anion chloride Cl- has been identified as the cause of the solubility decrease.
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Influence of pH, Temperature and Impurities on the Solubility of an Active Pharmaceutical Ingredient (API)
1Laboratoire de Génie Chimique CNRS UMR 5503, nicolas.estime@ensiacet.fr
2Laboratoire de Génie Chimique CNRS UMR 5503, sebastien.teychene@ensiacet.fr
3Institut de Recherche Pierre Fabre, jean.marie.autret@pierre-fabre.com
4Laboratoire de Génie Chimique CNRS UMR 5503, beatrice.biscans@ensiacet.fr
Citation Information: International Journal of Chemical Reactor Engineering. Volume 8, Issue 1, Pages –, ISSN (Online) 1542-6580, DOI: 10.2202/1542-6580.2099, May 2010
Publication History:
- Published Online:
- 2010-05-14
Keywords: solubility; API; impurity; pH
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