The packed bed columns with non-Newtonian liquid are increasing importance as a simple and inexpensive means of achieving yield of different chemical and biochemical processes though their hydrodynamic behavior is complex and not yet fully understood. In this article non-Newtonian flow behavior on frictional pressure was investigated in packed bed within a range of liquid velocity 0.004-0.04 m/s. The frictional pressure loss in non-Newtonian liquid system has been analyzed by modified Ergun equation. The modification of the Ergun equation is incorporated with the flow behavior index of non-Newtonian liquid. The degree of frictional pressure loss decreases with increase in flow behavior index. A correlation has been developed to interpret the degree of effect on the frictional pressure loss. The correlation may be useful for further understanding and scale-up of the packed bed column for its industrial application.