International Journal on Disability and Human Development
Official journal of the the National Institute of Child Health and Human Development in Israel
Editor-in-Chief: Merrick, Joav
Editorial Board Member: Brooks, Tony / Carmeli, BPT, Eliezer / Caron, MPH, Rosemary M. / Davidson, Philip W / Galil, Ahron / Heller, Tamar / Huff, Marlene B. / Janicki, Matthew P. / Kerr, Mike / Levy, Howard B / Lindström, Bengt / Morad, Mohammed / Omar, Hatim A. / Postolache, Teodor T. / Prasher, Vee / Shek, Daniel T.L. / Sher, Leo / Stratakis, Constantine A
SCImago Journal Rank (SJR) 2015: 0.210
Source Normalized Impact per Paper (SNIP) 2015: 0.280
Impact per Publication (IPP) 2015: 0.247
Psychiatric manifestations of latent toxoplasmosis. Potential mediation by indoleamine 2,3-dioxygenase
1Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
2University of South Florida College of Nursing, Tampa, FL, USA
3Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
Citation Information: International Journal on Disability and Human Development. Volume 9, Issue 1, Pages 3–10, ISSN (Online) 2191-0367, ISSN (Print) 2191-1231, DOI: 10.1515/IJDHD.2010.002, November 2010
- Published Online:
Toxoplasma gondii, a prevalent neurotropic parasite, induces immunological reactions that have the potential to affect brain and behavior. One possible connection between molecular mediators of inflammation (cytokines) and brain function and behavior is the activation of the enzyme indole-amine 2,3-dioxygenase, a mechanism implicated in containing T. gondii in the immunocompetent host, resulting in relative tryptophan depletion and kynurenine production. This could potentially lead to mood and behavioral dysregulation in latent toxoplasmosis.
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