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International Journal on Disability and Human Development

Official journal of the the National Institute of Child Health and Human Development in Israel

Editor-in-Chief: Merrick, Joav

Editorial Board Member: Brooks, Tony / Carmeli, Eli / Dalton, Arthur J / Davidson, Philip W / Galil, Ahron / Heller, Tamar / Huff, Marlene B. / Janicki, Matthew P. / Kerr, Mike / Levy, Howard B / Lindström, Bengt / Morad, Mohammed / Omar, Hatim A. / Prasher, Vee / Shek, Daniel T.L. / Sher, Leo / Stratakis, Constantine A / Postolache, Teodor T.

4 Issues per year

SCImago Journal Rank (SJR): 0.207
Source Normalized Impact per Paper (SNIP): 0.247



Psychiatric manifestations of latent toxoplasmosis. Potential mediation by indoleamine 2,3-dioxygenase

Baharak Khabazghazvini1 / Maureen Groer2 / Dietmar Fuchs3 / Paula Strassle1 / Manana Lapidus1 / Aamar Sleemi1 / Johanna B. Cabassa1 / Teodor T. Postolache1

1Mood and Anxiety Program, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA

2University of South Florida College of Nursing, Tampa, FL, USA

3Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria

Corresponding author: Teodor T. Postolache, MD, Mood and Anxiety Program (MAP), Department of Psychiatry, University of Maryland School of Medicine, 685 West Baltimore Street, MSTF Building Room 930, Baltimore, MD 21201, USA

Citation Information: International Journal on Disability and Human Development. Volume 9, Issue 1, Pages 3–10, ISSN (Online) 2191-0367, ISSN (Print) 2191-1231, DOI: 10.1515/IJDHD.2010.002, November 2010

Publication History

Published Online:


Toxoplasma gondii, a prevalent neurotropic parasite, induces immunological reactions that have the potential to affect brain and behavior. One possible connection between molecular mediators of inflammation (cytokines) and brain function and behavior is the activation of the enzyme indole-amine 2,3-dioxygenase, a mechanism implicated in containing T. gondii in the immunocompetent host, resulting in relative tryptophan depletion and kynurenine production. This could potentially lead to mood and behavioral dysregulation in latent toxoplasmosis.

Keywords: brain; depression; indoleamine 2,3-dioxygenase; schizophrenia toxoplasmosis

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