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International Journal of Occupational Medicine and Environmental Health


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Occupational Asthma Due to Manganese Exposure: A Case Report

Tomasz Wittczak1 / Wojciech Dudek1 / Anna Krakowiak1 / Jolanta Walusiak1 / Cezary Pałczyński1

Department of Occupational Diseases, Centre of Occupational and Environmental Allergy, Nofer Institute of Occupational Medicine, Łódź, Poland1

This content is open access.

Citation Information: International Journal of Occupational Medicine and Environmental Health. Volume 21, Issue 1, Pages 81–83, ISSN (Online) 1896-494X, ISSN (Print) 1232-1087, DOI: 10.2478/v10001-007-0041-1, March 2008

Publication History

Published Online:
2008-03-20

Occupational Asthma Due to Manganese Exposure: A Case Report

Manganese belongs to a group of agents called "transitional metals" that are known to induce occupational asthma. However, well-documented cases of manganese-induced asthma have been lacking thus far. We have discussed a case of a 42-year-old non-smoking welder with work-related dyspnea. A number of clinical procedures were performed including clinical examination, routine laboratory tests, total serum IgE, skin prick tests to common aeroallergens and manganese nitrate, resting spirometry test, histamine challenge, and a single-blind, placebo-controlled specific inhalation challenge with 0.1% manganese chloride solution. Clinical findings and laboratory test results remained normal but a significant bronchial hyperreactivity was found. During the specific inhalation challenge, dyspnea and a significant decrease in forced expiratory volume (FEV1) were observed. An increased proportion of eosinophils and basophils in induced sputum could also be noted at 4 and 24 h after the challenge. The argument for recognizing the condition as occupational asthma was a positive clinical response to the specific challenge test as well as the morphological changes found in induced sputum. To our knowledge, this is the first well-documented case of manganese-induced occupational asthma

Keywords: Manganese; Occupational asthma; Bronchial challenge

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