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International Journal of Occupational Medicine and Environmental Health


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Consequences of sleep deprivation

Jolanta Orzeł-Gryglewska1

Department of Animal Physiology, University of Gdańsk, Gdańsk, Poland1

This content is open access.

Citation Information: International Journal of Occupational Medicine and Environmental Health. Volume 23, Issue 1, Pages 95–114, ISSN (Online) 1896-494X, ISSN (Print) 1232-1087, DOI: 10.2478/v10001-010-0004-9, May 2010

Publication History

Published Online:
2010-05-04

Consequences of sleep deprivation

This paper presents the history of research and the results of recent studies on the effects of sleep deprivation in animals and humans. Humans can bear several days of continuous sleeplessness, experiencing deterioration in wellbeing and effectiveness; however, also a shorter reduction in the sleep time may lead to deteriorated functioning. Sleeplessness accounts for impaired perception, difficulties in keeping concentration, vision disturbances, slower reactions, as well as the appearance of microepisodes of sleep during wakefulness which lead to lower capabilities and efficiency of task performance and to increased number of errors. Sleep deprivation results in poor memorizing, schematic thinking, which yields wrong decisions, and emotional disturbances such as deteriorated interpersonal responses and increased aggressiveness. The symptoms are accompanied by brain tissue hypometabolism, particularly in the thalamus, prefrontal, frontal and occipital cortex and motor speech centres. Sleep deficiency intensifies muscle tonus and coexisting tremor, speech performance becomes monotonous and unclear, and sensitivity to pain is higher. Sleeplessness also relates to the changes in the immune response and the pattern of hormonal secretion, of the growth hormone in particular. The risk of obesity, diabetes and cardiovascular disease increases. The impairment of performance which is caused by 20-25 hours of sleeplessness is comparable to that after ethanol intoxication at the level of 0.10% blood alcohol concentration. The consequences of chronic sleep reduction or a shallow sleep repeated for several days tend to accumulate and resemble the effects of acute sleep deprivation lasting several dozen hours. At work, such effects hinder proper performance of many essential tasks and in extreme situations (machine operation or vehicle driving), sleep loss may be hazardous to the worker and his/her environment.

Keywords: Sleep deprivation; Slow-wave sleep; REM sleep; Sleeplessness; Deterioration of effectiveness; Impairment of performance

  • Bonnet MH, Arand DL. Clinical effects of sleep fragmentation versus sleep deprivation. Sleep Med Rev 2003;7:297-310. DOI 10.1053/smrv.2001.0245. [PubMed] [CrossRef]

  • Van Dongen HA, Maislin G, Mullington J, Dinges DF. The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. Sleep 2003;26:117-26. [PubMed]

  • Durmer JS, Dinges DF. Neurocognitive consequences of sleep deprivation. Semin Neurol 2005;25:117-29. [PubMed] [CrossRef]

  • Banks S, Dinges DF. Behavioral and physiological consequences of sleep restriction. J Clin Sleep Med 2007;3:519-28. [PubMed]

  • Monk TH, Welsh DK. The role of chronobiology in sleep disorders medicine. Sleep Med Rev 2003;7:455-73. DOI 10.1053/smrv.2002.0236. [PubMed] [CrossRef]

  • Akerstedt T. Shift work and disturbed sleep/wakefulness. Sleep Med Rev 1998;2:117-28. [PubMed] [CrossRef]

  • Kwarecki K, Zużewicz K. Patterns of sleep and locomotor activity in shift workers with special reference to night shift. Med Pr 2002;53:79-84 [in Polish].

  • Harma M, Hakola T, Kandolin I, Sallinen M, Virkkala J, Bonnefond A, et al. A controlled intervention study on the effects of a very rapidly forward rotating shift system on sleep-wakefulness and well-being among young and elderly shift workers. Int J Psychophysiol 2006;59:70-9. DOI 10.1016/j.ijpsycho.2005.08.005. [CrossRef]

  • Tamagawa R, Lobb B, Booth R. Tolerance of shift work. Appl Ergonom 2007;38:635-42. DOI 10.1016/j.apergo.2006.05.003. [CrossRef]

  • Haimov I, Arendt J. The prevention and treatment of jet lag. Sleep Med Rev 1999;3:229-40. [PubMed] [CrossRef]

  • Patrick GT, Gilbert JA. Studies from the psychological laboratory of the University of Iowa: On the effects of loss of sleep. Psychol Rev 1896;3:469-83. [CrossRef]

  • Kollar EJ, Namerow N, Pasnau RO, Naitoh P. Neurological findings during prolonged sleep deprivation. Neurology 1968;18:836-40. [PubMed] [CrossRef]

  • Pasnau RO, Naitoh P, Stier S, Kollar EJ. The psychological effects of 205 hours of sleep deprivation. Arch Gen Psychiatry 1968;18:496-505. [CrossRef]

  • Coren S. Sleep deprivation, psychosis and mental efficiency. Psychiatric Times 1998;15:1.

  • Gulevich G, Dement W, Johnson L. Psychiatric and EEG observations on a case of prolonged (264 h) wakefulness. Arch Gen Psychiatry 1966;15:29-35.

  • Horsnell M. Man who stayed up for 266 hours awakes to bad news. The Times 2007 May 26 (cited 2008 February 25). Available from: http://www.timesonline.co.uk/tol/news/uk/health/article1842716.ece

  • Ferrara M, De Gennaro L. How much sleep do we need? Sleep Med Rev 2001;5:155-79. DOI 10.1053/smrv.2000.0138. [PubMed] [CrossRef]

  • Youngstedt SD, Daniel F, Kripke DF. Long sleep and mortality: rationale for sleep restriction. Sleep Med Rev 2004;8:159-74. DOI 10.1016/j.smrv.2003.10.002. [PubMed] [CrossRef]

  • Gottlieb DJ, Punjabi NM, Newman AB, Resnick HE, Redline S, Baldwin CM, et al. Association of sleep time with diabetes mellitus and impaired glucose tolerance. Arch Intern Med 2005;165:863-7. [PubMed] [CrossRef]

  • Gottlieb DJ, Redline S, Nieto FJ, Baldwin CM, Newman AB, Resnick HE, et al. Association of usual sleep duration with hypertension: the Sleep Heart Health Study. Sleep 2006;29: 1009-14. [PubMed]

  • Webb WB. Some effects of prolonged sleep deprivation on the hooded rat. J Comp Physiol Psychol 1962;55:791-3. [PubMed] [CrossRef]

  • Rechtschaffen A, Gilliland MA, Bergmann BM, Winter JB. Physiological correlates of prolonged sleep deprivation in rats. Science 1983;221:182-4. [PubMed] [CrossRef]

  • Rechtschaffen A, Bergmann BM, Everson CA, Kushida CA, Gilliland MA. Sleep deprivation in the rat: I. Conceptual issues. Sleep 1989;12:1-4. [PubMed]

  • Rechtschaffen A, Bergmann BM, Everson CA, Kushida CA, Gilliland MA. Sleep deprivation in the rat: X. Integration and discussion of the findings. Sleep 1989;12:68-87. [PubMed]

  • Balzano S, Bergmann BM, Gilliland MA, Silva JE, Rechtschaffen A, Refetoff S. Effect of total sleep deprivation on 5'-deiodinase activity of rat brown adipose tissue. Endocrinology 1990;127:882-90. [CrossRef]

  • Rechtschaffen A, Bergmann BM. Sleep deprivation in the rat: an update of the 1989 paper. Sleep 2002;25:18-24.

  • Rechtschaffen A, Bergmann BM. Sleep deprivation in the rat by the disk-over-water method. Behav Brain Res 1995;69: 55-63. [CrossRef] [PubMed]

  • Everson CA, Bergmann BM, Rechtschaffen A. Sleep deprivation in the rat: III. Total sleep deprivation. Sleep 1989;12: 13-21. [PubMed]

  • Everson CA. Functional consequences of sustained sleep deprivation in the rat. Behav Brain Res 1995;69:43-54. [PubMed] [CrossRef]

  • Cirelli C, Shaw PJ, Rechtschaffen A, Tononi G. No evidence of brain cell degeneration after long-term sleep deprivation in rats. Brain Res 1999;840:184-93. [CrossRef] [PubMed]

  • Everson CA, Gilliland MA, Kushida CA, Pilcher JJ, Fang VS, Refetoff S, et al. Sleep deprivation in the rat: IX. Recovery. Sleep 1989;12:60-7. [PubMed]

  • Schwierin B, Borbely AA, Tobler I. Prolonged effects of 24-h total sleep deprivation on sleep and sleep EEG in the rat. Neurosci Lett 1999;261:61-4. [CrossRef]

  • Sgoifo A, Buwalda B, Roos M, Costoli T, Merati G, Meerlo P. Effects of sleep deprivation on cardiac autonomic and pituitary-adrenocortical stress reactivity in rats. Psychoneuroendocrinology 2006;31:197-208. DOI 10.1016/j.psyneuen.2005.06.009. [PubMed] [CrossRef]

  • Siegel JM. Clues to the functions of mammalian sleep. Nature 2005;437:1264-1271. DOI 10.1038/nature04285. [PubMed] [CrossRef]

  • Lyamin O, Pryaslova J, Lance V, Siegel J. Animal behaviour: continuous activity in cetaceans after birth. Nature 2005;435:1177. DOI 10.1038/4351177a. [CrossRef] [PubMed]

  • Marinesco S, Bonnet C, Cespuglio R. Influence of stress duration on the sleep rebound induced by immobilization in the rat: a possible role for corticosterone. Neuroscience 1999;92: 921-33. [CrossRef]

  • Rampin C, Cespuglio R, Chastrette N, Jouvet M. Immobilisation stress induces a paradoxical sleep rebound in rat. Neurosci Lett 1991;126:113-8. [CrossRef] [PubMed]

  • Newman SM, Paletz EM, Rattenborg NC, Obermeyer WH, Benca RM. Sleep deprivation in the pigeon using the disk-over-water method. Physiol Behav 2008;93:50-8. DOI 10.1016/j.physbeh.2007.07.012. [PubMed] [CrossRef]

  • Siegel JM. Do all animals sleep? Trends Neurosci 2008;31: 208-13. DOI 10.1016/j.tins.2008.02.001 [CrossRef] [PubMed]

  • Borbély AA, Tobler I, Hanagasioglu M. Effect of sleep deprivation on sleep and EEG power spectra in the rat. Behav Brain Res 1984;14:171-82. [PubMed] [CrossRef]

  • Elmenhorst E-M, Elmenhorst D, Luks N, Maass H, Vejvoda M, Samel A. Partial sleep deprivation: impact on the architecture and quality of sleep. Sleep Medicine 2008;9: 840-50. DOI 10.1016/j.sleep.2007.07.021. [CrossRef] [PubMed]

  • Endo T, Schwierin B, Borbely AA, Tobler I. Selective and total sleep deprivation: effect on the sleep EEG in the rat. Psychiatr Res 1997;66:97-110. [CrossRef]

  • Suchecki D, Palma BD, Tufik S. Sleep rebound in animals deprived of paradoxical sleep by the modified multiple platform method. Brain Res 2000;875:14-22. [CrossRef] [PubMed]

  • Kushida CA, Bergmann BM, Rechtschaffen A. Sleep deprivation in the rat: IV. Paradoxical sleep deprivation. Sleep 1989;12:22-30. [PubMed]

  • Nykamp K, Rosenthal L, Folkerts M, Roehrs T, Guido P, Roth T. The effects of REM sleep deprivation on the level of sleepiness/alertness. Sleep 1998;21:609-14. [PubMed]

  • Ferraz MR, Ferraz MMD, Santos R. How REM sleep deprivation and amantadine affects male rat sexual behavior. Pharmacol Biochem Behav 2001;69:325-32. [PubMed] [CrossRef]

  • Damasceno F, Skinner GO, Cordeiro JF, Ferraz MR, Almeida OM. Sleep deprivation affects sexual behavior and tyrosine hydroxylase (TH) levels in sexually experienced male rats. Physiol Behav 2008;94:405-11. DOI 10.1016/j.physbeh.2008.02.008. [CrossRef] [PubMed]

  • Gilliland MA, Bergmann BM, Rechtschaffen A. Sleep deprivation in the rat: VIII. High EEG amplitude sleep deprivation. Sleep 1989;12:53-9. [PubMed]

  • Wilkinson RT. Muscle tension during mental work under sleep deprivation. J Exp Psychol 1962;64:565-71. [CrossRef] [PubMed]

  • Veldhuizen IJ, Gaillard AW, de Vries J. The influence of mental fatigue on facial EMG activity during a simulated workday. Biol Psychol 2003;63:59-78. [PubMed] [CrossRef]

  • Arihara M, Sakamoto K. Contribution of motor unit activity enhanced by acute fatigue to physiological tremor of finger. Electromyograph Clin Neurophysiol 1999;39:235-47.

  • Morrison S, Kavanagh J, Obst SJ, Irwin J, Haseler LJ. The effects of unilateral muscle fatigue on bilateral physiological tremor. Exp Brain Res 2005;167:609-21. [PubMed] [CrossRef]

  • Patel M, Gomez S, Berg S, Almbladh P, Lindblad J, Petersen H, et al. Effects of 24-h and 36-h sleep deprivation on human postural control and adaptation. Exp Brain Res 2008;185: 165-73.

  • Fabbri M, Martoni M, Esposito MJ, Brighetti G, Natale V. Postural control after a night without sleep. Neuropsychologia 2006;44:2520-2525. DOI 10.1016/j.neuropsychologia.2006.03.033. [CrossRef] [PubMed]

  • Gomez S, Patel M, Berg S, Magnusson M, Johansson R, Fransson PA. Effects of proprioceptive vibratory stimulation on body movement at 24 and 36 h of sleep deprivation. Clin Neurophysiol 2008;119:617-25. DOI 10.1016/j.clinph.2007.10.058. [CrossRef]

  • Caldwell JA, Prazinko B, Caldwell JL. Body posture affects electroencephalographic activity and psychomotor vigilance task performance in sleep-deprived subjects. Clin Neurophysiol 2003;114:23-31. [CrossRef] [PubMed]

  • Souissi N, Sesboüé B, Gauthier A, Larue J, Davenne D. Effects of one night's sleep deprivation on anaerobic performance the following day. Eur J Appl Physiol 2003;89:359-66. [CrossRef]

  • Reilly T, Edwards B. Altered sleep-wake cycles and physical performance in athletes. Physiol Behav 2007;90:274-84. DOI 10.1016/j.physbeh.2006.09.017. [PubMed] [CrossRef]

  • Thomas ML, Sing HC, Belenky G, Holcomb HH, Mayberg HS, Dannals RF, et al. Neural basis of alertness and cognitive performance impairments during sleepiness II. Effects of 48 and 72 h of sleep deprivation on waking human regional brain activity. Thalamus Related Syst 2003;2:199-229. DOI 10.1016/S1472-9288(03)00020-7. [CrossRef]

  • Roge J, Pebayle T, Kiehn L, Muzet A. Alteration of the useful visual field as a function of state of vigilance in simulated car driving. Transportation Res 2002;Part F 5:189-200.

  • Roge J, Pebayle T, El Hannachi S, Muzet A. Effect of sleep deprivation and driving duration on the useful visual field in younger and older subjects during simulator driving. Vision Res 2003;43:1465-72. DOI 10.1016/S0042-6989(03)00143-3. [CrossRef] [PubMed]

  • Kendall AP, Kautz MA, Russo MB, Killgore WD. Effects of sleep deprivation on lateral visual attention. Int J Neurosci 2006;116:1125-38. [CrossRef] [PubMed]

  • Killgore WD, McBride SA. Odor identification accuracy declines following 24 h of sleep deprivation. J Sleep Res 2006;15:111-6. [CrossRef]

  • Onen SH, Alloui A, Gross A, Eschallier A, Dubray C. The effects of total sleep deprivation, selective sleep interruption and sleep recovery on pain tolerance thresholds in healthy subjects. J Sleep Res 2001;10:35-42. [CrossRef] [PubMed]

  • Lautenbacher S, Kundermann B, Krieg J-Ch. Sleep deprivation and pain perception. Sleep Med Rev 2006;10:357-69. DOI 10.1016/j.smrv.2005.08.001. [CrossRef]

  • Taffinder NJ, McManus IC, Gul Y, Russell RCG, Darzi A. Effect of sleep deprivation on surgeons' dexterity on laparos-copy simulator. Lancet 1998;352:1191. [CrossRef]

  • Kahol K, Leyba MJ, Deka M, Deka V, Mayes S, Smith M, et al. Effect of fatigue on psychomotor and cognitive skills. Am J Surg 2008;195:195-204. DOI 10.1016/j.amj-surg.2007.10.004. [CrossRef] [PubMed]

  • Harrison Y, Horne JA. Sleep deprivation affects speech. Sleep 1997;20:871-7. [PubMed]

  • Harrison Y, Horne JA. One night of sleep loss impairs innovative thinking and flexible decision making. Org Behav Human Decision Proc 1999;78:128-45.

  • Killgore WD, Balkin TJ, Wesensten NJ. Impaired decision making following 49 h of sleep deprivation. J Sleep Res 2006;15:7-13.

  • Kushida CA, Everson CA, Suthipinittharm P, Sloan J, Soltani K, Bartnicke B, et al. Sleep deprivation in the rat: VI. Skin changes. Sleep 1989;12:42-6. [PubMed]

  • Brandenberger G, Gronfier C, Chapotot F, Simon C, Piquard F. Effect of sleep deprivation on overall 24 h growth-hormone secretion. Lancet 2000;356:1408. [CrossRef]

  • Brandenberger G, Weibel L. The 24-h growth hormone rhythm in men: sleep and circadian influences questioned. J Sleep Res 2004;13:251-5. [CrossRef]

  • Everson CA, Toth LA. Systemic bacterial invasion induced by sleep deprivation. Am J Physiol Regulatory Integrative Comp Physiol 2000;278:905-16.

  • Mostaghimi L, Obermeyer WH, Ballamudi B, Martinez-Gonzalez D, Benca RM. Effects of sleep deprivation on wound healing. J Sleep Res 2005;14:213-9. [CrossRef] [PubMed]

  • Kiecolt-Glaser JK, Marucha PT, Malarkey WB, Mercado AM, Glaser R. Slowing of wound healing by psychological stress. Lancet 1995;346:1194-6. [CrossRef]

  • Martins PJ, D'Almeida V, Nobrega JN, Tufik S. A reassessment of the hyperphagia/weight-loss paradox during sleep deprivation. Sleep 2006;29:1233-8.

  • Koban M, Sita LV, Le WW, Hoffman GE. Sleep deprivation of rats: the hyperphagic response is real. Sleep 2008;31:927-33. [PubMed]

  • Spiegel K, Tasali E, Penev P, Van Cauter E. Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med 2004;141:846-50. [CrossRef] [PubMed]

  • Knutson KL, Spiegel K, Penev P, Van Cauter E. The metabolic consequences of sleep deprivation. Sleep Med Rev 2007;11:163-78. DOI 10.1016/j.smrv.2007.01.002. [CrossRef] [PubMed]

  • Hasler G, Buysse DJ, Klaghofer R, Gamma A, Ajdacic V, Eich D, et al. The association between short sleep duration and obesity in young adults: a 13-year prospective study. Sleep 2004;27:661-6.

  • Gangwisch JE, Malaspina D, Boden-Albala B, Heymsfield SB. Inadequate sleep as a risk factor for obesity: analyses of the NHANES I. Sleep 2005;28:1289-96. [PubMed]

  • Bjorvatn B, Sagen IM, Oyane N, Waage S, Fetveit A, Pallesen S, et al. The association between sleep duration, body mass index and metabolic measures in the Hordaland Health Study. J Sleep Res 2007;16:66-76. [CrossRef] [PubMed]

  • Snell EK, Adam EK, Duncan GJ. Sleep and the body mass index and overweight status of children and adolescents. Child Develop 2007;78:309-23. [CrossRef]

  • Chaput J-P, Després J-P, Bouchard C, Tremblay A. The association between sleep duration and weight gain in adults: a 6-year prospective study from the Quebec family study. Sleep 2008;31:517-23.

  • Bergmann BM, Everson CA, Kushida CA, Fang VS, Leitch CA, Schoeller DA, et al. Sleep deprivation in the rat: V. Energy use and mediation. Sleep 1989;12:31-41. [PubMed]

  • Parekh PI, Ketter TA, Altshuler L, Frye MA, Callahan A, Marangell L, et al. Relationship between thyroid hormone and antidepressant responses to total sleep deprivation in mood disorder patients. Biol Psychiatry 1998;43:392-4. [CrossRef] [PubMed]

  • Fadda P, Fratta W. Stress-induced sleep deprivation modifies corticotropin releasing factor (CRF) levels and CRF binding in rat brain and pituitary. Pharmacol Res 1997;35:443-6. [PubMed] [CrossRef]

  • Schussler P, Uhr M, Ising M, Weikel JC, Schmid DA, Held K, et al. Nocturnal ghrelin, ACTH, GH and cortisol secretion after sleep deprivation in humans. Psychoneuroendocrinology 2006;31:915-23. DOI 10.1016/j.psyneuen.2006.05.002. [PubMed] [CrossRef]

  • Charloux A, Gronfier C, Chapopot F, Ehrhart J, Piquard F, Brandenberger G. Sleep deprivation blunts the nighttime increase in aldosterone release in humans. J Sleep Res 2001;10:27-33. [CrossRef]

  • Dickstein JB, Moldofsky H. Sleep, cytokines and immune function. Sleep Med Rev 1999;3:219-28. [CrossRef] [PubMed]

  • Krueger JM, Obál FJ, Fang J, Kubota T, Taishi P. The role of cytokines in physiological sleep regulation. Ann NY Acad Sci 2001;933:211-21.

  • Pietruczuk K, Jakuszkowiak K, Nowicki Z, Witkowski JM. Cytokines in sleep regulation and disturbances. Sen 2003;3: 127-33 [in Polish].

  • Majde JA, Krueger JM. Links between the innate immune system and sleep. J Allergy Clin Immunol 2005;116: 1188-98. DOI 10.1016/j.jaci.2005.08.005 [CrossRef] [PubMed]

  • Opp MR. Cytokines and sleep. Sleep Med Rev 2005;9: 355-64. DOI 10.1016/j.smrv.2005.01.002. [PubMed] [CrossRef]

  • Benca RM, Kushida CA, Everson CA, Kalski R, Bergmann BM, Rechtschaffen A. Sleep deprivation in the rat: VII. Immune function. Sleep 1989;12:47-52. [PubMed]

  • Toth LA, Tolley EA, Krueger JM. Sleep as a prognostic indicator during infectious disease in rabbits. Proc Soc Exp Biol Med 1993;203:179-92. [CrossRef] [PubMed]

  • Toth LA. Sleep, sleep deprivation and infectious disease: studies in animals. Adv Neuroimmunol 1995;5:79-92. [PubMed] [CrossRef]

  • Everson CA. Sleep deprivation in rats results in systemic infection without a febrile response. Sleep Res 1993;22:2162.

  • Dinges DF, Douglas SD, Hamarman S, Zaugg L, Kapoor S. Sleep deprivation and human immune function. Adv Neuroimmunol 1995;5:97-110. DOI 10.1016/j.smrv.2006.07.001. [PubMed] [CrossRef]

  • Jurkowski MK, Bobek-Billewicz B. Influence of sleep deprivation on immunity. Sen 2002;2:95-8 [in Polish].

  • Bentivoglio M, Kristensson K. Neural-immune interactions in disorders of sleep-wakefulness organization. Trends Neurosci 2007;30:645-52. DOI 10.1016/j.tins.2007.09.004. [PubMed] [CrossRef]

  • Hui L, Hua F, Diandong H, Hong Y. Effects of sleep and sleep deprivation on immunoglobulins and complement in humans. Brain Behav Immun 2007;21:308-10. DOI 10.1016/j.bbi.2006.09.005. [PubMed] [CrossRef]

  • Irwin M, Mascovich A, Gillin JC, Willoughby R, Pike J, Smith TL. Partial sleep deprivation reduces natural killer cell activity in humans. Psychosom Med 1994;56:493-8. [PubMed]

  • Irwin MN, Gillin JC, Fortner M, Costlow C. Depression: sleep and immunity. Biol Psychiatry 1997;42:9s. [CrossRef]

  • Öztürk L, Pelin Z, Karadeniz D, Kaynak H, Çakar L, Gözükirmizi E. Effects of 48 hours sleep deprivation on human immune profile. Sleep Res Online 1999;2:107-11.

  • Thomas M, Sing H, Belenky G, Holcomb H, Mayberg H, Dannals R, et al. Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity. J Sleep Res 2000;9:335-52. [CrossRef]

  • Drummond SPA, Gillin JC, Brown GG. Increased cerebral response during a divided attention task following sleep deprivation. J Sleep Res 2001;10:85-92. [PubMed] [CrossRef]

  • Szelenberger W, Piotrowski T, Dαbrowska AJ. Increased prefrontal event-related current density after sleep deprivation. Acta Neurobiol Exp 2005;65:19-28.

  • Gosselin A, De Koninck J, Campbell KB. Total sleep deprivation and novelty processing: implications for frontal lobe functioning. Clin Neurophysiol 2005;116:211-22. DOI 10.1016/j.clinph.2004.07.033. [CrossRef] [PubMed]

  • Cajochen C, Foy R, Dijk D-J. Frontal predominance of a relative increase in sleep delta and theta EEG activity after sleep loss in humans. Sleep Res Online 1999;2:65-9 (cited 2004 December 29). Available from: http://www.sro.org/1999/Cajochen/65/ http://www.sro.org/1999/Cajochen/65/

  • Nofzinger EA. Neuroimaging and sleep medicine. Sleep Med Rev 2005;9:157-72. DOI 10.1016/j.smrv.2004.07.003. [PubMed] [CrossRef]

  • Caldwell JA, Prazinko BF, Kecia K, Hall KK. The effects of body posture on resting electroencephalographic activity in sleep-deprived subjects. Clin Neurophysiol 2000;111: 464-70. [PubMed] [CrossRef]

  • Li N, Wang Y, Wang M, Liu H. Effects of sleep deprivation on gamma oscillation of waking human EEG. Prog Nat Sci 2008;18:1533-7. DOI 10.1016/j.pnsc.2008.05.021. [CrossRef]

  • Jin S-H, Na SH, Kim SY, Kim D-J. Effects of total sleep-deprivation on waking human EEG: functional cluster analysis. Clin Neurophysiol 2004;115:2825-33. DOI 10.1016/j.clinph.2004.07.001. [CrossRef] [PubMed]

  • Badawy RA, Curatolo JM, Newton M, Berkovic SF, Macdonell RA. Sleep deprivation increases cortical excitability in epilepsy: syndrome-specific effects. Neurology 2006;67:1018-22. [PubMed] [CrossRef]

  • Barbini B, Bertelli S, Colombo C, Smeraldi E. Sleep loss, a possible factor in augmenting manic episode. Psychiatr Res 1996;65:121-5. [CrossRef]

  • Gessa GL, Pani L, Fadda P, Fratta W. Sleep deprivation in the rat: an animal model of mania. Eur Neuropsychopharmacol 1995;Suppl.:89-93. [PubMed]

  • Killgore WD, Kahn-Greene ET, Lipizzi EL, Newman RA, Kamimori GH, Balkin TJ. Sleep deprivation reduces perceived emotional intelligence and constructive thinking skills. Sleep Med 2008;9:517-26. DOI 10.1016/j.sleep.2007.07.003. [PubMed] [CrossRef]

  • Kahn-Greene ET, Lipizzi EL, Conrad AK, Kamimori GH, Killgore WD. Sleep deprivation adversely affects interpersonal responses to frustration. Personal Individ Differ 2006;41:1433-43. DOI 10.1016/j.paid.2006.06.002. [CrossRef]

  • Kahn-Greene ET, Killgore DB, Kamimori GH, Balkin TJ, Killgore WD. The effects of sleep deprivation on symptoms of psychopathology in healthy adults. Sleep Med 2007;8: 215-21. DOI 10.1016/j.sleep.2006.08.007. [CrossRef]

  • Dahl RE. Sleeplessness and aggression in youth. J Adolesc Health 2006;38:641-2. DOI 10.1016/j.jado-health.2006.03.013. [CrossRef] [PubMed]

  • Wirz-Justice A, Van den Hoofdakker RH. Sleep deprivation in depression: what do we know, where do we go? Biol Psychiatry 1999;46:445-53. [CrossRef]

  • Giedke H, Schwarzler F. Therapeutic use of sleep deprivation in depression. Sleep Med Rev 2002;6:361-77. DOI 10.1053/smrv.2002.0235. [CrossRef] [PubMed]

  • Vogel GW. Evidence for rem sleep deprivation as the mechanism of action of antidepressant drugs. Prog Neuropsycho-pharmacol Biol Psychiatry 1983;7:343-9.

  • Clark CP, Frank LR, Brown GG. Sleep deprivation, EEG, and functional MRI in depression: preliminary results. Neuropsychopharmacology 2001;25:79-84. [CrossRef]

  • Demet E, Chicz-Demet A, Fallon JH, Sokolski KN. Sleep deprivation therapy in depressive illness and Parkinson's disease. Prog Neuropsychopharmacol Biol Psychiat 1999;23:753-84. [CrossRef]

  • Wu JC, Buchsbaum M, Bunney Jr WE. Clinical neurochemical implications of sleep deprivation's effects on the anterior cingulate of depressed responders. Neuropsychopharmacology 2001;25:74-8. [CrossRef]

  • Stickgold R. Sleep-dependent memory consolidation. Nature 2005;437:1272-8. DOI 10.1038/nature04286. [PubMed] [CrossRef]

  • Stickgold R, Walker MP. Sleep-dependent memory consolidation and reconsolidation. Sleep Med 2007;8:331-43. DOI 10.1016/j.sleep.2007.03.011 [PubMed] [CrossRef]

  • Smith C, Gisquet-Verrier P. Paradoxical sleep deprivation and sleep recording following training in a brightness discrimination avoidance task in Sprague-Dawley rats: paradoxical effects. Neurobiol Learn Memory 1996;66:283-94. [CrossRef]

  • Vertes RP. Memory consolidation in sleep: dream or reality. Neuron 2004;44:135-48. [CrossRef] [PubMed]

  • Smith C. Sleep states and memory processes. Behav Brain Res 1995;69:137-45. [PubMed] [CrossRef]

  • Smith CT, Conway JM, Rose GM. Brief paradoxical sleep deprivation impairs reference, but not working, memory in the radial arm maze task. Neurobiol Learn Memory 1998;69:211-7. [CrossRef]

  • Guan Z, Peng X, Fang J. Sleep deprivation impairs spatial memory and decreases extracellular signal-regulated kinase phosphorylation in the hippocampus. Brain Res 2004;1018:38-47. DOI 10.1016/j.brainres.2004.05.032. [CrossRef]

  • Silva RH, Chehin AB, Kameda SR, Takatsu-Coleman AL, Abilio VC, Tufik S, et al. Effects of pre- or post-training paradoxical sleep deprivation on two animal models of learning and memory in mice. Neurobiol Learn Memory 2004;82: 90-8. DOI 10.1016/j.nlm.2004.04.005. [CrossRef]

  • Ficca G, Salzarulo P. What in sleep is for memory. Sleep Med 2004;5:225-30. DOI 10.1016/j.sleep.2004.01.018. [PubMed] [CrossRef]

  • Rauchs G, Desgrandes B, Foret J, Eustache F. The relationships between memory systems and sleep stages. J Sleep Res 2005;14:123-40. [CrossRef] [PubMed]

  • Turner TH, Drummond SPA, Salamat JS, Brown GG. Effects of 42 hr of total sleep deprivation on component processes of verbal working memory. Neuropsychology 2007;21:787-95.

  • Koehl M, Battle S, Meerlo P. Sex differences in sleep: the response to sleep deprivation and restraint stress in mice. Sleep 2006;29:1224-31. [PubMed]

  • Andersen ML, Antunes IB, Silva A, Alvarenga TAF, Baracat EC, Tufik S. Effects of sleep loss on sleep architecture in Wistar rats: gender-specific rebound sleep. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:975-83. DOI 10.1016/j.pnpbp.2008.01.007 [PubMed] [CrossRef]

  • Corsi-Cabrera M, Sanchez AI, del-Rio-Portilla Y, Villanueva Y, Perez-Garci E. Effect of 38 h of total sleep deprivation on the waking EEG in women: sex differences. Int J Psychophysiol 2003;50:213-24. DOI 10.1016/S0167-8760(03)00168-5. [CrossRef]

  • Blatter K, Graw P, Munch M, Knoblauch V, Wirz-Justice A, Cajochen C. Gender and age differences in psychomotor vigilance performance under differential sleep pressure conditions. Behav Brain Res 2006;168:312-7. DOI 10.1016/j.bbr.2005.11.018. [CrossRef] [PubMed]

  • Acheson A, Richards JB, de Wit H. Effects of sleep deprivation on impulsive behaviors in men and women. Physiol Behav 2007;91:579-87. DOI 10.1016/j.physbeh.2007.03.020. [PubMed] [CrossRef]

  • Stutts JC, Wilkins JW, Osberg JS, Vaughn BV. Driver risk factors for sleep-related crashes. Accid Anal Prev 2003;35: 321-31. [CrossRef] [PubMed]

  • Peters RD, Wagner E, Alicandri E, Fox JE, Thomas ML, Thorne DR, et al. Effects of partial and total sleep deprivation on driving performance. Public Roads 1999;62 (4): 2-8.

  • Philip P, Sagaspe P, Moore N, Taillard J, Charles A, Guilleminault C, et al. Fatigue, sleep restriction and driving performance. Accid Anal Prev 2005;37:473-8. DOI 10.1016/j.aap.2004.07.007. [CrossRef]

  • Bougard C, Moussay S, Davenne D. An assessment of the relevance of laboratory and motorcycling tests for investigating time of day and sleep deprivation influences on motorcycling performance. Accid Anal Prev 2008;40:635-43. DOI 10.1016/j.aap.2007.09.002. [PubMed] [CrossRef]

  • Pack AI, Pack AM, Rodgman E, Cucchiara A, Dinges DF, Schwab CW. Characteristics of crashes attributed to the driver having fallen asleep. Accid Anal Prev 1995;27:769-75. [CrossRef] [PubMed]

  • Smulders FT, Kenemans JL, Jonkman LM, Kok A. The effects of sleep loss on task performance and the electroencephalogram in young and elderly subjects. Biol Psychol 1997;45:217-39. [CrossRef]

  • Philip P, Taillard J, Sagaspe P, Valtat C, Sanchez-Ortuno M, Moore N, et al. Age, performance and sleep deprivation. J Sleep Res 2004;13:105-10. [PubMed] [CrossRef]

  • Muzur A, Pace-Schott EF, Hobson JA. The prefrontal cortex in sleep. Trends Cogn Sci 2002;6:475-81. [PubMed] [CrossRef]

  • Lamond N, Dawson D. Quantifying the performance impairment associated with fatigue. J Sleep Res 1999;8:255-62. [PubMed]

  • Williamson AM, Feyer A-M. Moderate sleep deprivation produces impairments in cognitive and motor performance equivalent to legally prescribed levels of alcohol intoxication. Occup Environ Med 2000;57:649-55. [PubMed] [CrossRef]

  • Arnedt JT, Wilde GJS, Munt PW, MacLean AW. How do prolonged wakefulness and alcohol compare in the decrements they produce on a simulated driving task? Accid Anal Prev 2001;33:337-44. [CrossRef] [PubMed]

  • Fletcher A, Lamond N, van den Heuvel CJ, Dawson D. Prediction of performance during sleep deprivation and alcohol intoxication using a quantitative model of work-related fatigue. Sleep Res Online 2003;5(2):67-75 [cited 2008 Feb 28]. Available from: http://www.sro.org/2003/Fletcher/67/. http://www.sro.org/2003/Fletcher/67/

  • Maruff P, Falleti MG, Collie A, Darby D, McStephen M. Fatigue-related impairment in the speed, accuracy and variability of psychomotor performance: comparison with blood alcohol levels. J Sleep Res 2005;14:21-7. [CrossRef] [PubMed]

  • Tietzel A, Lack LC. The recuperative value of brief and ultrabrief naps on alertness and cognitive performance. J Sleep Res 2002;11:213-8. [CrossRef]

  • Brooks A, Lack L. A brief afternoon nap following nocturnal sleep restriction: which nap duration is most recuperative? Sleep 2006;29:831-40. [PubMed]

  • Hayashi M, Abe A. Short daytime naps in a car seat to counteract daytime sleepiness: The effect of backrest angle. Sleep Biol Rhythms 2008;6:34-41. DOI 10.1111/j.1479-8425.2008.00333.x. [CrossRef]

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