This article describes the implementation and evaluation of a program to prepare HIV Nurse Practitioners in Zambia. Thirty nurses from all nine Zambian provinces participated in this program. Data on a variety of indicators were collected at baseline and throughout the one-year program including student and supervisor assessments, student performance on pre- and post-tests, clinical and case study assessments, documentation of care in patients’ health records, and their performance on final oral and written examinations. Findings indicated that the students were able to achieve the identified competencies and that their supervisors perceived that they would be able to implement their expanded skills to improve care for patients with HIV and AIDS in Zambia. Lessons learned from this initial pilot project will be used to expand the program in order to ensure successful task-shifting to address the critical shortage of health workers in Zambia in the context of the HIV/AIDS epidemic.