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International Journal of Occupational Medicine and Environmental Health


IMPACT FACTOR 2013: 1.094
5-year IMPACT FACTOR: 1.400

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Adverse effects of antioxidative vitamins

1Department of Clinical Chemistry and Biochemistry, Medical University of Łódź, Łódź, Poland

2Department of Endoscopy and One Day Gastroenterology, Wł. Biegański Memorial Regional Specialistic Hospital, Łódź, Poland

3Department of Endoscopy and One Day Gastroenterology, Wł. Biegański Memorial Regional Specialistic Hospital, Kniaziewicza 1/5, 91-347, Łódź, Poland

Citation Information: International Journal of Occupational Medicine and Environmental Health. Volume 25, Issue 2, Pages 105–121, ISSN (Online) 1896-494X, DOI: 10.2478/s13382-012-0022-x, April 2012

Publication History

Published Online:
2012-04-19

Abstract

High doses of synthetic antioxidative vitamins: A, E, C and β-carotene are often used on long-term basis in numerous preventive and therapeutic medical applications. Instead of expected health effects, the use of those vitamins may however lead to cases of hypervitaminosis and even to intoxication. The article points out main principles of safety which are to be observed during supplementation with antioxidative vitamins. Toxic effects resulting from erroneous administration of high doses of those substances on organs and systems of the organism are also discussed. Attention is drawn to interactions of antioxidative vitamins with concomitantly used drugs, as well as intensification of adverse effects caused by various exogenous chemical factors. Moreover, the article presents the evaluation of supplementation with these vitamins, which was performed in large studies.

Keywords: Vitamins A, E and C; β-carotene; Supplementation; Side actions; Toxic effects

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