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Interdisciplinary Toxicology

The Journal of Institute of Experimental Pharmacology of Slovak Academy of Sciences

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Catabolism of hyaluronan: Involvement of transition metals

Ladislav Šoltés1 / Grigorij Kogan1

Institute of Experimental Pharmacology, Slovak Academy of Sciences, SK-84104 Bratislava, Slovakia1

Directorate Health, Directorate General Research, European Commission, B-1049, Brussels, Belgium2

This content is open access.

Citation Information: Interdisciplinary Toxicology. Volume 2, Issue 4, Pages 229–238, ISSN (Online) 1337-9569, ISSN (Print) 1337-6853, DOI: 10.2478/v10102-009-0026-y, January 2010

Publication History

Published Online:
2010-01-06

Catabolism of hyaluronan: Involvement of transition metals

One of the very complex structures in the vertebrates is the joint. The main component of the joint is the synovial fluid with its highmolar-mass glycosaminoglycan hyaluronan, which turnover is approximately twelve hours. Since the synovial fluid does not contain any hyaluronidases, the fast hyaluronan catabolism is caused primarily by reductive-oxidative processes.

Eight transition metals - V23, Mn25, Fe26, Co27, Ni28, Cu29, Zn30, and Mo42 - naturally occurring in living organism are essential for the control of various metabolic and signaling pathways. They are also the key elements in catabolism of hyaluronan in the joint.

In this overview, the role of these metals in physiological and pathophysiological catabolism of hyaluronan is described. The participation of these metals in the initiation and propagation of the radical degradation hyaluronan is critically reviewed.

Keywords: hyaluronan catabolism; synovial fluid; joint; transition metals; peroxidation; oxidative stress

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