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Jerte Valley cherry-based product modulates serum inflammatory markers in rats and ringdoves
Technological Agri-food Institute (INTAEX), Badajoz, Spain1
Department of Physiology* Neuroimmunophysiology and Chrononutrition Research Group* Faculty of Science, University of Extremadura, Badajoz, Spain2
Citation Information: Journal of Applied Biomedicine. Volume 10, Issue 1, Pages 41–50, ISSN (Online) 1214-0287, ISSN (Print) 1214-021X, DOI: 10.2478/v10136-011-0009-0, February 2012
- Published Online:
Jerte Valley cherry-based product modulates serum inflammatory markers in rats and ringdoves
Ageing is commonly accompanied by a chronic subclinical inflammatory status that coexists with immune dysfunction. Consumption of foods rich in antioxidants is associated with a lower incidence of chronic diseases. The aim of this study was to evaluate the effect of the consumption of a Jerte Valley cherry-based beverage on the inflammatory load in two different animal species: rats and ringdoves (Streptopelia risoria); each divided into two age groups. To this purpose, circulating levels of both pro-inflammatory (IL-1β and TNF-α) and anti-inflammatory (IL-4 and IL-2) cytokines were measured before and after a 10-day treatment with the Jerte Valley cherry-based beverage. Our results suggest that the 10-day treatment with the Jerte Valley cherry-based beverage modulated the balance of pro- and anti-inflammatory cytokines in both rats and ringdoves by down-regulating the levels of pro-inflammatory (IL-1β and TNF-α) cytokines and up-regulating the levels of anti-inflammatory (IL-4 and IL-2) cytokines. Moreover, old animals showed imbalanced levels of inflammatory markers towards a pro-inflammatory status, thereby underlining the fact that ageing is usually accompanied by systemic inflammation and inflammation-related chronic diseases. In conclusion, since an increased dietary intake of vegetable-derived bioactive compounds may retard age-related immune dysfunctions and prolong life-span, supplementing diets with the cherry-based beverage may reduce the inflammatory load by modulating the serum concentrations of some markers of inflammation.