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Publication Date:
October 2011
ISSN:
2191-0286
DOI:
10.1515/JBCPP.2011.023

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Journal of Basic and Clinical Physiology and Pharmacology

Editor-in-Chief: Horowitz, Michal

Editorial Board Member: Das, Kusal K. / Devor, Marshall / Epstein, Yoram / S. Gershon MD, Elliot / Haim, Abraham / Kohen, Ron / Lichtstein, David / Maloyan, Alina / Mechoulam, Raphael / Shohami, Esther / Sohmer, Haim / Yoshikawa, Toshikazu / Ilani, Asher / Ringel, Israel / Youdim, Moussa B.H.

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In vitro antibacterial activity of nanoconjugated vancomycin against plasmid mediated intraspecies and interspecies transfer of vancomycin resistance

Subhankari Prasad Chakraborty1 / Panchanan Pramanik2 / 1

1Immunology and Microbiology Laboratory, Department of Human Physiology with Community Health, Vidyasagar University, Midnapore, West Bengal, India

2Nanomaterials Laboratory, Department of Chemistry, Indian Institute of Technology, Kharagpur, West Bengal, India

Corresponding author: Dr. Somenath Roy, Professor, Immunology and Microbiology Laboratory, Department of Human Physiology with Community Health, Vidyasagar University, Midnapore 721 102, West Bengal, India Phone/Fax: +91-3222-275329,

Citation Information: Journal of Basic and Clinical Physiology and Pharmacology. Volume 22, Issue 4, Pages 121–129, ISSN (Online) 2191-0286, ISSN (Print) 0792-6855, DOI: 10.1515/JBCPP.2011.023, October 2011

Publication History:
Received:
2011-07-22
Accepted:
2011-09-16
Published Online:
2011-10-25

Abstract

Background: The aim of the present study was to observe the plasmid mediated intraspecies and interspecies transfer of vancomycin resistance, and possible antibacterial activity of nanoconjugated vancomycin against such resistant.

Methods: Plasmids were isolated from a chosen vancomycin resistant Staphylococcus aureus strain (MMC-17). The obtained 890 bp plasmid was then transferred to vancomycin sensitive S. aureus (MMC-6) and Escherichia coli (RGK 26) strains.

Results: The vancomycin sensitive S. aureus and E. coli developed vancomycin resistance. Plasmid analysis of the transformed MMC-6 and RGK 26 revealed that it contains 890 bp plasmid corresponding to the donor S. aureus, which may harbor the vanA gene. Nanoconjugated vancomycin shows its efficient drug action through transport of vancomycin into transformed MMC-6 and RGK 26.

Conclusions: Plasmid mediated intraspecies and interspecies transfer of vancomycin resistance is accomplished by the vanA gene. Nanoconjugated vancomycin shows effective drug delivery in plasmid mediated vancomycin resistance in S. aureus and E. coli.

Keywords: disc agar diffusion; minimum inhibitory concentration; nanoconjugated vancomycin; plasmid; tolerance; vancomycin resistant Staphylococcus aureus

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