Journal of Basic and Clinical Physiology and Pharmacology
Editor-in-Chief: Horowitz, Michal
Editorial Board Member: Das, Kusal K. / Epstein, Yoram / S. Gershon MD, Elliot / Haim, Abraham / Kodesh , Einat / Kohen, Ron / Lichtstein, David / Maloyan, Alina / Mechoulam, Raphael / Roth, Joachim / Schneider, Suzanne / Shohami, Esther / Sohmer, Haim / Yoshikawa, Toshikazu
4 Issues per year
SCImago Journal Rank (SJR): 0.224
Source Normalized Impact per Paper (SNIP): 0.383
Volume 25 (2014)
Volume 24 (2013)
Volume 23 (2012)
Volume 22 (2011)
Volume 21 (2010)
Volume 20 (2009)
Volume 19 (2008)
Volume 18 (2007)
Volume 17 (2006)
Volume 16 (2005)
Volume 14 (2003)
Volume 13 (2002)
Volume 12 (2001)
Volume 11 (2000)
Volume 10 (1999)
Volume 8 (1997)
Volume 7 (1996)
Volume 6 (1995)
Volume 4 (1993)
Volume 3 (1992)
Volume 2-3 (1992)
Volume 2 (1991)
Volume 1 (1990)
Most Downloaded Articles
- Israel Society for Auditory Research (ISAR): 2013 Annual Scientific Conference by Avraham, Karen B.
- Israeli Society for Auditory Research (ISAR): 2012 Annual Scientific Conference
- Hormone-brain-aging relationships, broadly reactive with imidazole-containing dipeptides: targeting of telomere attrition as an aging biomarker and dynamic telomerase activity flirting by Babizhayev, Mark A./ Vishnyakova, Khava S. and Yegorov, Yegor E.
Biochemical and morphological changes in Trypanosoma brucei brucei- infected rats treated with homidium chloride and diminazene aceturate
1Department of Chemical Sciences, College of Natural Sciences, Redeemer’s University, Mowe, Nigeria
2Department of Biochemistry, University of Ilorin, Ilorin, Nigeria
Citation Information: Journal of Basic and Clinical Physiology and Pharmacology. Volume 23, Issue 4, Pages 179–183, ISSN (Online) 2191-0286, ISSN (Print) 0792-6855, DOI: 10.1515/jbcpp-2012-0018, October 2012
- Published Online:
Background: Chemotherapy which is one of the major methods for controlling trypanosomal infections is beset with several challenges including unwanted toxicity and limited efficacy. These factors and others underscore research efforts aimed at finding safer and more effective therapeutic agents for trypanosomiasis. Homidium chloride and diminazene aceturate are registered drugs for the treatment of animal trypanosomiasis.
Methods: Study investigated and compared, in an experimental Trypanosoma infection, the effects of two trypanocides on the pathology of tissues and some biochemical indices in rats.
Results: Data revealed that the levels of alkaline phosphatase, alanine transaminase and aspartate transaminase in infected positive animals were significantly (p<0.05) elevated relative to uninfected negative controls but showed no significant difference when compared with the trypanocide-treatment groups. The histopathological presentations in the infected and treatment groups are a demonstration of the inimical cellular alterations associated with Trypanosoma brucei brucei infection.
Conclusions: The inimical alterations to biochemical and morphological parameters observed in the infected as well as the treatment groups is an implication suggesting shortcomings of the investigated trypanocides to alleviate pathology associated with Trypanosoma brucei brucei infection. We present evidence that further supports the urgent need for the development of safer and more effective trypanocides.