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Journal of Basic and Clinical Physiology and Pharmacology

Editor-in-Chief: Horowitz, Michal

Editorial Board Member: Das, Kusal K. / Epstein, Yoram / S. Gershon MD, Elliot / Haim, Abraham / Kodesh , Einat / Kohen, Ron / Lichtstein, David / Maloyan, Alina / Mechoulam, Raphael / Roth, Joachim / Schneider, Suzanne / Shohami, Esther / Sohmer, Haim / Yoshikawa, Toshikazu

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Toxicological evaluations of methanolic extract of Moringa oleifera leaves in liver and kidney of male Wistar rats

1 / Temitayo O. Omobowale2 / Ibraheem O. Azeez1 / John O. Abiola2 / Rahamon A.M. Adedokun2 / Helen O. Nottidge2

1Faculty of Veterinary Medicine, Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Oyo State, Nigeria

2Faculty of Veterinary Medicine, Department of Veterinary Medicine, University of Ibadan, Oyo State, Nigeria

Corresponding author: Ademola A. Oyagbemi, Faculty of Veterinary Medicine, Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Oyo State, Nigeria, Phone: +2348033639776, Fax: +234028103043, E-mail:

Citation Information: Journal of Basic and Clinical Physiology and Pharmacology. Volume 24, Issue 4, Pages 307–312, ISSN (Online) 2191-0286, ISSN (Print) 0792-6855, DOI: 10.1515/jbcpp-2012-0061, March 2013

Publication History

Received:
2012-10-10
Accepted:
2013-02-24
Published Online:
2013-03-18

Abstract

Background: This study was conducted to investigate toxicological effects associated with prolonged consumption of Moringa oleifera leaves as a beverage.

Methods: Thirty rats were used in this study. They were grouped into five groups of six rats. Rats in group I received 2 mL/kg body weight (b.w.) of corn oil (vehicle). Animals in groups II, III, IV and V received 50, 100, 200 and 400 mg/kg b.w. of methanolic extract of M. oleifera (MEMO) for 8 weeks. Serum collected was analyzed for alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein, albumin, globulin, blood urea nitrogen (BUN) and creatinine.

Results: There was a significant (p<0.05) increase in serum total protein and globulin in a dose-dependent manner. Rats that received MEMO at 200 and 400 mg/kg b.w. showed a significant (p<0.05) increase in serum ALT, AST, BUN and creatinine which pointed to hepatic and kidney damage. All experimental animals that received MEMO had a significant (p<0.05) increase in body weight in a dose-dependent manner.

Conclusions: This study therefore confirms for the first time that chronic administration of M. oleifera leaves might predispose to hepatic and kidney damage.

Keywords: kidney; liver; Moringa oleifera; toxicity assessment

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