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Aims and Scope
The Journal of Complementary and Integrative Medicine focuses on evidence concerning the efficacy and safety of complementary and alternative medical (CAM) whole systems, practices, interventions and natural health products, including herbal medicines. To facilitate information transfer to the consumer, summaries of each article will also be published in easy-to understand and colloquial language. When feasible, selected articles will be published in other languages to facilitate distribution of information to a larger international community. The journal is edited by Ed Lui of the University of Western Ontario.
- Type of Publication:
Journal of Complementary and Integrative Medicine focuses on evidence concerning the efficacy and safety of complementary and alternative medical (CAM) whole systems, practices, interventions and natural health products, including herbal medicines. To facilitate information transfer to the consumer, summaries of each article will also be published in easy-to understand and colloquial language. When feasible, selected articles will be published in other languages to facilitate distribution of information to a larger international community. The journal is edited by Ed Lui of the University of Western Ontario.
One issue/year, updated continuously
Content available since 2004 (Volume 1, Issue 1)
Instructions for Authors
Journal of Complementary and Integrative Medicine – Information for Authors
1. Scope and policy of the Journal
The Journal of Complementary and Integrative Medicine (JIM) publishes Research Articles, Review Articles, Mini Reviews, Case Reports (see Appendix 1), Discussion Papers, and Short Communications on Medicinal Herbs and Complementary Therapies (see Appendix 2) on evidence concerning the efficacy and safety of complementary and alternative medical (CAM) whole systems, practices, interventions and natural health products, including herbal medicines. JCIM also publishes Editorials, Opinions Papers, Conference Abstracts, Presentations and Proceedings, Innovation in CAM Curriculum and Educational Material Design. Review Articles and Mini Reviews are normally published by invitation, but suggestions to the Editors are welcome. Articles in JCIM are published in English. Manuscripts are reviewed by two independent reviewers selected by the Editors. JCIM aspires to notify authors about the decision within approx. 10-12 weeks from submission date. When manuscripts are accepted subject to revision, the revised manuscript should be returned within approx. 6 weeks. Accepted articles are published online ahead of print approx. 3–4 weeks after acceptance.
Reviewers: The authors should provide the names and e-mail addresses of up to 3 potential reviewers. Authors may also indicate names of reviewers whom they wish to be excluded from reviewing their manuscripts.
Unpublished material: Submission of a manuscript to JCIM implies that the work described has not been published previously, except in the form of an abstract, academic thesis or lecture; that it is not under consideration for publication elsewhere; that publication of the work is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out; and that, if accepted, it will not be published elsewhere, in English, German, or in any other language, without the written consent of the Publisher.
Ethical conduct of research: Work involving humans should comply with the principles laid down in the Declaration of Helsinki, adopted by the 18th World Medical Assembly, Helsinki, Finland, June 1964, and recently amended at the 59th World Medical Assembly, Seoul, Korea, October 2008. In the text, , or in a separate section, the manuscript should contain a statement that the study has been approved by the Ethical Committee of the institution where the study was performed, and that the study subjects, or their legal guardians, gave informed consent for participation in the study.
Conflict of interest: Submission to JCIM requires a Conflict of Interest Declaration. Upon submission, you will be required to complete and upload a form to declare any conflicts of interest, funding, employment, or leadership and honoraria. This information must also be included in your manuscript before the Reference section. If you have no declaration to make, please insert None declared. A conflict of interest for a given manuscript exists when a participant in the peer review and publication process – author, reviewer, and editor – has ties to activities that could inappropriately influence his or her judgment, regardless of whether judgment is, in fact, affected. Financial relationships with industry (for example, employment, consultancies, stock ownership, honoraria, expert testimony), either directly or through immediate family, are usually considered the most important conflicts of interest. However, conflicts can occur for other reasons, such as financial support of the study, ties to health insurance, politics or other stakeholders, personal relationships, academic competition, and intellectual passion.
Copyright: Manuscripts are accepted on condition of transfer of copyright (for U.S. government employees: to the extent transferable) to the publisher. Once the manuscript has been accepted, it may not be published elsewhere without the consent of the copyright holders.
2. Submission of manuscripts
Please submit manuscripts exclusively online at:
3. Preparation of manuscripts
Language: Manuscripts should be written in clear and concise English. Please have your text proofread by a native English speaker before you submit it for consideration. At proof stage, only minor changes other than corrections of printers’ errors are allowed.
Cover letter: Each manuscript should be accompanied by a cover letter containing a brief statement by the authors describing the novelty and importance of their research.
General format and length: Type the manuscript (including table legends, figure legends and references) double-spaced using 12 pt font size. Do not use footnotes in the text, use parentheses instead.
When you submit your work, please ensure the following:
• The manuscript is complete and uploaded correctly. (The PDF file generated from the submitted files must be approved.)
• The full names of all authors are provided (personal name, middle initials, family name).
• Author affiliations are complete.
• All Figures and Tables have been uploaded and appear correctly at the end of the PDF.
• Abstract, Keywords, List of Abbreviations, Tables and Figures, and captions and legends are included.
• Number of words, Figures, Tables, and References are indicated on the title page.
• Manuscript is spell-checked and within the word limit for the type of article.
• Manuscripts must be written in clear and concise English.
• References are in the correct format (Vancouver style) and cited sequentially in the text.
• References mentioned in the reference list are cited in the text and vice versa.
• Ethical approval has been obtained and mentioned in the text, if applicable.
• Authors’ conflict of interest declaration is included.
• A cover letter containing a brief statement describing the novelty and importance of the work is included.
• The names and e-mail addresses of up to three potential reviewers, preferably not from the same country as the authors, should be included (does not apply to invited articles).
• SI units are used.
• Numbers have decimal points, no commas, also in Tables and Figures.
• Supplier name, city and country are provided for reagents and apparatus reported in the manuscript.
Review articles (Mini reviews)
1. The topic must be current.
2. The scope of the manuscript should not exceed 7500 (3500) words, excluding references, captions and Tables.
3. The composition is not defined, however, the following parts are required: Title page, Abstract (unstructured; 250 words maximum), 3-6 Keywords, Introduction, Acknowledgments and a List of non-standard abbreviations, if applicable, References (150 (40) references maximum), Tables and Figures, if applicable, including titles and legends, and a Conflict of interest statement.
1. The manuscript should not exceed 4500 words, excluding references, captions and Tables.
2. The manuscript should have Title page, Abstract (structured into Background, Methods, Results and Conclusions; 250 word maximum), 3-6 Keywords, Introduction, Materials and methods, Results, Discussion, Acknowledgments and a List of non-standard abbreviations, if applicable, References (50 references maximum), Tables and Figures, if applicable, including titles and legends (8 Tables/Figures maximum), and a Conflict of interest statement. The title should be short and precise. In the Discussion, the results should be interpreted and critically reviewed and judged compared to the work of other laboratories working in the same scientific area. The clinical relevance of the research should also be presented.
1. The manuscript should not exceed 1500 words, excluding references, captions and Tables.
2. The manuscript should have Title page, Abstract (structured into Background, Methods, Results and Conclusions; 250 word maximum), 3-6 Keywords, text (without cross headings), Acknowledgments and a List of non-standard abbreviations, if applicable, References (15 references maximum), Tables and Figures, if applicable, including titles and legends (2 Tables or 2 Figures, or 1 Table and 1 Figure maximum), and a Conflict of interest statement. Experimental procedures should be described in the legends to Figures and Tables.
1. The topic must be current.
2. The scope of the manuscript should not exceed 3500 words, excluding references, captions and Tables.
3. The composition is not defined, however, the following parts are required: Title page, Abstract (unstructured; 250 words maximum), 3-6 Keywords, Introduction, Acknowledgments and a List of non-standard abbreviations, if applicable, References (40 references maximum), 2-4 Tables and/or Figures, if applicable, including titles and legends, and a Conflict of interest statement.
References: Adhere strictly to the reference style of the Journal (Vancouver; recommendations of the “International Committee of Medical Journals Editors"; see N Engl J Med 1991;324:421–8). All references mentioned in the Reference list must be mentioned in the text, and vice versa. List and number the references consecutively in the order that they appear in the text, including Tables and Figures. In the text, identify references by Arabic numerals in parentheses. Italic and boldface font type in the Reference section is not allowed. List all authors; if the number is 7 or more, list the first 6 names followed by et al. Identify authors by last name first, followed by up to 2 initials, without periods, indicating the authors’ first name. Only the first name of the title is capitalized, as well as proper names within the title. Journal names are abbreviated according to the World List of Scientific Periodicals, without periods. After the abbreviated journal name, give the year of publication, followed by a semicolon, volume number (but no issue number), followed by a double colon, and the page numbers, with the last page number in shortened format. Meeting abstracts may be cited only if published in journals. Unpublished observations and personal communications are cited only in the text. Correct linking of the references depends on strict adherence to Journal style.
• Articles in journals: Söderberg J, Jonsson AP, Wallin O, Grankvist K, Hultdin J. Haemolysis index – an estimate of preanalytical quality in primary health care. Clin Chem Lab Med 2009;47:940–4.
• Articles ahead of print: Joventino IP, Alves HG, Neves LC, Pinheiro-Joventino F, Leal, Luzia KA, Neves SA, et al. The microalga Spirulina platensis presents anti-inflammatory action as well as hypoglycemic and hypolipidemic properties in diabetic rats. J Complement Integr Med 2012;9. Epub ahead of print 13 Dec 2011. DOI: 10.1515/1553-3840.1534.
• Supplements: Ploder M, Schroecksnadel K, Spittler A, Neurauter G, Roth E, Fuchs D. Moderate hyperhomocysteinema in trauma and sepsis indicates poor survival. Clin Chem Lab Med 2009;47:Suppl:S187.
• Books and Monographs: Kahn CR, Weir GC, editors. Joslin’s diabetes mellitus, 13th ed. Philadelphia: Lea and Febiger, 1994:1068.
• Chapters: Karnofsky DH, Burchenal JH. The clinical evaluation of chemotherapeutic agents in cancer. In: Macleod CM, editor. Evaluation of chemotherapeutic agents. New York: Columbia University Press, 1949:191–205.
• Website: World Health Organization. WHO information for laboratory
diagnosis of pandemic (H1N1) 2009 virus in humans update. Available
Diagnostic_RecommendationsH1N1_20090521. pdf. Accessed: 6 Nov
Tables: Number Tables consecutively using Arabic numerals. Provide a short descriptive title, column headings, and (if necessary) footnotes to make each Table self-explanatory. In the footnote, refer to information within the Table with superscript lowercase letters, and do not use special characters or numbers. Separate units with a comma and use parentheses or square brackets for additional measures (e.g., %, range, etc). Refer to Tables in the text as Table 1, etc. Use Table 1 (boldface), etc. in the title of the Table.
Figures: General requirements. All illustrations must be of reproduction-ready quality. They will be reduced in size to fit, whenever possible, the width of a single column. Lettering of all Figures within the article should be uniform in style (preferably a sans serif typeface like Helvetica) and of sufficient size (ca. 10 pt.). Uppercase letters A, B, C, etc. should be used to identify parts of multi-part Figures. In the legend, these letters are included in parentheses. Cite
all Figures in the text in numerical order. Indicate the approximate placement of each Figure. Do not embed Figures within the text body of the manuscript..
Halftone figures and line drawings Figures should have a minimum resolution of 300 dpi (halftone figures) and 1200 dpi (line drawings) and be of good contrast. Faint shading may be lost upon reproduction. When drawing bar graphs, use patterning instead of grayscales.
Color plates. Authors are encouraged to submit illustrations in color if necessary for the scientific content of their work. Publication of color Figures is provided free of charge both in online and print editions.
Figure legends Provide a short descriptive title and a legend, either below the Figure or on separate pages, to make each Figure self-explanatory. Explain all symbols used in a Figure. Remember to use the same abbreviations as in the text body.
Supplemental material: You may submit Supplemental data, i.e. additional tables, figures, videos, appendices or other additional material (e.g. references) that exceeds the limitation of the article and/or illustrates the contents of your article, e.g.
• visual presentation of signs
• treatment or intervention approaches
Supplemental data should be uploaded as separate file(s) during submission. Within the text, Supplemental data must be cited consecutively and be referred to as Supplemental data (e.g. see Supplemental data, Figure 1). Supplemental data is subject to peer review as part of the manuscript. If the manuscript is accepted and the Supplemental data is posted online, it will be referenced in the article of the printed version together with the URL where it can be found.
Nomenclature: Follow the rules of the IUPAC-IUB Commission on Biochemical Nomenclature, as in IUB Biochemical Nomenclature and Related Documents, 3rd ed., obtainable from Biochemical Society Book Depot, P.O. Box 32, Commerce Way, Colchester, CO2 8HP, U.K. Enzyme names should be in accordance with the recommendations of the IUPAC-IUB Commission on Biochemical Nomenclature, 1978, as in Enzyme Nomenclature, published by Academic Press, New York, 1992. Genotypes should be given in italics, phenotypes should not be italicized. Nomenclature of bacterial genetics should follow Damerec et al. Genetics 1966; 54:61–76.
Note for authors of NIH-funded research: De Gruyter acknowledges that the author of a US-agency-funded article retains the right to provide a copy of the final manuscript to agency upon acceptance for publication or thereafter, for public archiving in PubMed Central 12 months after publication in JCIM. Note that only the accepted author’s version of the manuscript, not the PDF
file of the published article, may be used for NIH archiving.
Permissions: It is the authors’ responsibility to obtain permission to reproduce original or modified material that has been previously published elsewhere.
Proofs: The corresponding author of an article will receive the proofs in electronic form to check for editing and type-setting accuracy. Major changes to the article as accepted for publication will not be considered at this stage, unless the authors pay for these changes.
Offprints: The electronic files of typeset articles in Adobe Acrobat PDF format are provided free of charge; corresponding authors receive notification that their article has been published online. Paper offprints can be ordered in addition; an offprint order form will accompany the page proofs and should be completed and returned with the corrected proofs immediately if offprints are requested.
Please contact the Editorial Office with any further questions:
Heike Jahnke, T: +49 30 26005-220, F: +49 30 26005-325, E-mail: heike.jahnke@deGruyter.com
We will do our best to assist you.
Type of publication:
Standardized Case Reports for Novel Complementary or Integrative Medicine Interventions or Therapies
Purpose of a clinical case report is to document a unique observational study of a patient or patients (or subjects) which provides education, new understanding and knowledge of patient care that may stimulate further scientific inquiry.
Area of reporting (Category): efficacy, safety, and interactions with other therapies as pertained to herbal or traditional medicine and different complementary therapies.
Who should consider publishing: all recognized health care providers including CAM practitioners, pharmacists, physicians, and nurse practitioners.
Nature or scope of the report:
• Description of unusual outcomes or “Best Case” without established causality
• Case report with emphasis on educational objectives to inform about novel therapies or interventions, including N=1 studies.
• Innovative/unusual or rare cases, idiosyncratic reactions, including description of temporal relationship, identification and validation of Natural Health Products involved in the report
• Withdrawal and rechallenge outcomes
• Cases leading to hypothesis generation
1. Introduction/Background information
What is the case about?
o An unexpected association between diseases or symptoms.
o An unexpected event in the course of observing or treating a patient.
o Findings that shed new light on the possible cause of a disease or an adverse effect.
o Unique or rare features of a disease.
o Unique therapeutic approaches.
The characteristics of intervention to be reported. It must be well documented based on available evidence and references.
Importance of the case being presented and why it is being reported
2. Case description
o Chief complaint and present medical history
o Past medical, family and social histories
o Physical examination
o Laboratory findings
o Nature of Therapy or Intervention
o Description of how the intervention was administered, by whom, for how long etc
o For adverse event associated with exposure, identity and authentication of purported agent(s) involved, and possible contaminants
o Information about concomitant therapies or exposure to drugs and supplements, confounding factors etc clearly described
o Re-challenge for validation if any
3. Results or outcome of intervention
• All pertinent findings are clearly stated: relevant positive and pertinent negative results
• Information presented in chronological order: timelines for both administration of the intervention (therapy), duration of treatment and relationship results must be clearly stated
• Possible causal relationship:
• Biological plausibility?
• Alternative explanations
• Relevant published reports
• New hypothesis
• Future study
7. Conflict of interest statement
Type of publication:
Short Communication on Medicinal Herbs and Complementary Therapies
• Name of plant(s):
o Botanical name
o Botanical binomial name
o Common name
• Primary biological activity examined
• Name of authors and affiliations
Picture of plant used if any
• Traditional use
• Known pharmacological or biological activity
• Rationale for the study
2. Materials used in the study
• Raw herbs
• Types of extract
• Methodology for:
3. Biological activity examined and name of analyses (basis of the choose if available)
• Statistical analysis
4. Research findings
6. Significance, applications and implications
8. Supplemental data
Supplemental data required (mandatory requirement, published as supplemental file)
• Methodology used and data obtained including chemical profile of extract
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Edmund M. K. Lui, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario
Kelvin Chan, University of Sydney & University of Western Sydney, Australia
Robert Kam-Ming Ko, Hong Kong University of Science and Technology, Hong Kong, China
Kelvin Sze-Yin Leung, Hong Kong Baptist University, Kowloon, Hong Kong, China
Paul Saunders, Can College of Naturopathic Medicine, Toronto, Ontario, Canada
Carmen Tamayo, Director, Division of Complementary and Alternative Medicine, Foresight Links Corporation, Bethesda, MD, USA
Zhang-Jin Zhang, University of Hong Kong, Hong Kong, China
John T. Arnason, Department of Biology, University of Ottawa, Ottawa Ontario, Canada
Steven K.H. Aung, Associate Clinical Professor, Departments of Medicine and Family, Medicine University of Alberta, Alberta, Canada
Robert Banner, Department of Anesthesia and Perioperative Medicine, University of Western Ontario, London, Ontario
Zhao Xiang Bian, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China
Heather Boon, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
Alieen P. Burford-Mason, DRS Consulting, Toronto, Ontario, Canada
Harpal S. Buttar, Senior Scientist and Adjunct Professor, Reproduction and Urology Division, Therapeutic Products Directorate, Ottawa, Ontario, Canada
Ke-Ji Chen, Xiyuan Hospital, Beijing, China
Mottie Chevion, Hadassah School of Medicine, The Hebrew University, Israel
Patrick C. Chow, Department of Biochemistry & Medical Genetics, University of Manitoba, Manitoba, Canada
Simon Chiu, Department of Psychiatry University of Western Ontario, London, Ontario
Jean-Paul Collet, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
Trish Dryden, Massage Therapy Program, Centennial College, Scarborough, Ontario, Canada
Nina L. Etkin, Chair, Department of Anthropology, University of Hawaii, Honolulu, Hawaii
Jeanette Ezzo, University of Maryland, Maryland, USA
Barbara Findlay, Integrated Health Care Consultant, Richmond, BC, Canada
Gerhard Franz, Fakulta Fur Chemie/Pharmazie, University of Regensburg, Germany
Mahabir Gupta, Facultad de Farmacia, Universidad de Panama, Rep. de Panamá
Maurice Hirst, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario
Freddie-Ann Hoffman, HeteroGeneity, LLC, Washington, DC, USA
Zhuohan Hu, Research Institute for Liver Diseases (Shanghai) and Faculty of Pharmacy, Fudan University, China
Tannis M. Jurgens, College of Pharmacy, Dalhousie University, NS, Canada
Allan S.Y. Lau, Department of Paediatrics and Adolescent Medicine, University of Hong Kong, Hong Kong
Francis C.P. Law, Faculty of Biological Sciences, Simon Fraser University, Burnaby, BC, Canada
P.C. Leung, Institue Of Chinese Medicine, Chinese University of Hong Kong, Hong Kong, China
Maria Lara Marquez, Dept. of Allergy and Clinical Immunology, Children's Hospital ¨J.M. de Los Rios, Caracas, Venezuela
Patrica Morley-Forster, Department of Anaesthesia and Perioperative Care, University of Western Ontario, London, Ontario, Canada
Pulok K. Mukherjee, Natural Product Studies Lab, Dept. of Pharmaceutical Technology, Jadavpur University, India
Liliana Pazos, Laboratorio de Ensayos Biologicos, Universidad de Costa Rica, San Jose, Costa Rica
Gregor Reid, Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada
Mary Ann Richardson, National Foundation for Alternative Medicine, Washington, DC, USA
Catherine Ulbricht, Natural Standard Research Collaboration, Massachusetts General Hospital, Boston, USA
Mary Wu, Toronto School of Traditional Chinese Medicine, Toronto, Ontario, Canada