Oxidative stress due to abnormal production of reactive oxygen species (ROS) is believed to be involved in the etiology of toxicity of many xenobiotics. Evidence suggests that in cisplatin-induced nephrotoxicity, ROS is involved. We studied the nephroprotective effects of ethanol extract of Embelia ribes fruits alone and in combination with vitamin E (?-tocopherol) in cisplatin (12mg/kg i.p)-induced nephrotoxicity in mice. The results of the study indicated that Embelia ribes fruits significantly and dose dependently protected the cisplatin-induced nephrotoxicity. The serum urea, creatinine and blood urea nitrogen levels in cisplatin alone treated groups were significantly elevated (P < 0.01) with respect to control group. The serum urea, creatinine and blood urea nitrogen levels were reduced in the Embelia ribes fruits extract treated (200 and 400 mg/kg, p.o), vitamin E (200 mg/kg, p.o), and Embelia ribes fruits (200 mg/kg) with vitamin E (200 mg/kg, p.o) treated groups. The renal levels of reduced glutathione (GSH) were declined in cisplatin alone treated groups. The level of GSH was elevated significantly (P < 0.01) in the Embelia ribes fruits (200 and 400 mg/kg) and Embelia ribes fruits (200 mg/kg) with vitamin E (200 mg/kg) treated groups. The results also demonstrated that combination of Embelia ribes fruits (200 mg/kg) with vitamin E (200 mg/kg) showed a better protection compared to their 200 mg/kg alone treated groups.