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Ko, Robert / Leung, Kelvin Sze-Yin / Tamayo, Carmen / Zhang, Zhang-Jin

Journal of Complementary and Integrative Medicine

Editor-in-Chief: Lui, Edmund

4 Issues per year

Hepatoprotective Effects and Antioxidant Role of Scutia myrtina on Paracetamol Induced Hepatotoxicity in Rats

Ramanathan Sambath Kumar1 / Kupusamy Asokkumar2 / Nallasamy Venkateswara Murthy3

1Seventh of April University

2Seventh of April University

3J.K.K. Nataraja College of Pharmacy

Citation Information: Journal of Complementary and Integrative Medicine. Volume 8, Issue 1, ISSN (Online) 1553-3840, DOI: 10.2202/1553-3840.1461, February 2011

Publication History

Published Online:

The hepatoprotective effect and antioxidant role of ethanol extract of Scutia myrtina (EESM) was evaluated against paracetamol induced liver damage in rats. The degree of protection was measured by using biochemical parameters such as serum transaminase (SGPT and SGOT), alkaline phosphatase (ALP), bilirubin, total protein and uric acid. Further, the effects of the extract on lipid peroxidation (LPO), glutathione (GSH), Vitamin C and Vitamin E, superoxide dismutase (SOD), and catalase (CAT) were estimated. The ethanol extract of Scutia myrtina (EESM) (100 and 200 mg/kg) produced significant (P < 0.05) hepatoprotective effect by decreasing the activity of serum enzymes, bilirubin, and lipid peroxidation, while it significantly increased the levels of protein, uric acid, GSH, Vitamin C, Vitamin E, SOD and CAT (P < 0.05). The effects of EESM were comparable to that of standard drug Silymarin. The results indicate that EESM shows hepatoprotective effects on paracetamol-induced liver damage in rat this may due to antioxidant and free radical scavenging activity of EESM.

Keywords: Scutia myrtina; hepatoprotective effects; antioxidant; paracetamol; serum enzyme

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