Journal of Complementary and Integrative Medicine
Editor-in-Chief: Lui, Edmund
Editorial Board Member: Chan, Kelvin / Ko, Robert / Leung, Kelvin Sze-Yin / Tamayo, Carmen / Zhang, Zhang-Jin
4 Issues per year
SCImago Journal Rank (SJR) 2014: 0.203
Source Normalized Impact per Paper (SNIP) 2014: 0.290
Impact per Publication (IPP) 2014: 0.655
Volume 12 (2015)
Volume 11 (2014)
Volume 10 (2013)
Volume 9 (2012)
Volume 8 (2011)
Volume 7 (2010)
Volume 6 (2009)
Volume 5 (2008)
Volume 4 (2007)
Volume 3 (2006)
Volume 2 (2005)
Volume 1 (2004)
Most Downloaded Articles
- 2014 IN-CAM Research Symposium: The Next Wave of Complementary and Integrative Medicine and Health Care Research by Boon, Heather/ Kania-Richmond, Ania/ Verhoef, Marja J./ Tsui, Teresa and Danelesko, Elaine
- Phytonutrients as therapeutic agents by Gupta, Charu and Prakash, Dhan
- Is yoga an effective treatment in the management of patients with chronic low back pain compared with other care modalities – a systematic review by Hill, Christopher
The Microalga Spirulina platensis Presents Anti-inflammatory Action as well as Hypoglycemic and Hypolipidemic Properties in Diabetic Rats
1G&F Spirulina do Brasil M.E.
2Faculty of Medicine of Juazeiro Do Norte, Brazil
3Faculty of Medicine of Juazeiro Do Norte, Brazil
4G&F Spirulina do Brasil M.E.
5Federal University of Ceará, Brazil
6Faculty of Medicine of Juazeiro Do Norte, Brazil
7Federal University of Ceará, Brazil
8Federal University of Ceará, Brazil
9G&F Spirulina do Brasil M.E.
Citation Information: Journal of Complementary and Integrative Medicine. Volume 9, Issue 1, ISSN (Online) 1553-3840, DOI: 10.1515/1553-3840.1534, August 2012
- Published Online:
Spirulina platensis (Spi) is a microalga presenting high contents of proteins, γ-linolenic acid, vitamins and minerals, and showing many biological activities. It is a promising drug for the treatment of diseases including diabetes. The objectives of this work were to study Spi effects on alloxan-induced diabetic rats, and associate this to its anti-inflammatory activity. The treatment with Spi (25, 50 or 100 mg/kg, p.o.) started 48 h after the alloxan injection, continuing for 5 or 10 days. Biochemical parameters were measured in sera of treated and untreated animals. The anti-inflammatory activity of Spi was assessed by the formalin test and carrageenan-induced paw edema in mice. Immunostainings for TNF-alpha were carried out in the carrageenan-induced paw edema in rats, before and after the Spi treatment, and its effect on the release of myeloperoxidase from human neutrophils was also determined. Spi decreased glycemia as well as triglyceride and total cholesterol levels of diabetic rats. Levels of urea and creatinine were also reduced, while liver transaminases were unaltered. Spi also decreased dose-dependently the 1st (neurogenic) and mainly the 2nd phase (inflammatory) of the formalin test, as well as the carrageenan-induced paw edema in mice. The anti-inflammatory effect of Spi was further confirmed by decreases in TNF-alpha immunostaining in the inflamed paw and in the myeloperoxidase release from human neutrophils. The results showed that the anti-diabetic effect of S. platensis is already manifested after a 5-day treatment. Additionally, considering the relationship between diabetes and inflammation, the microalga anti-inflammatory action may also be involved.
Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.