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Ko, Robert / Leung, Kelvin Sze-Yin / Tamayo, Carmen / Zhang, Zhang-Jin

Journal of Complementary and Integrative Medicine

Editor-in-Chief: Lui, Edmund

4 Issues per year

The use of an anti-inflammatory supplement in patients with chronic kidney disease

1Professor of Health Education and Associate Dean for Graduate Studies and Research, Baylor University, Waco, Texas USA

2Baylor University, Waco, TX, United States

3Texas Lutheran University, Austin, Texas USA

4Family Health Center

5Brazos, Kidney Disease Center

6Western University of Health Sciences, Pomona, CA 91766, United States

7Victoria University, Melbourne, Australia

Citation Information: Journal of Complementary and Integrative Medicine. Volume 10, Issue 1, Pages 143–152, ISSN (Online) 1553-3840, ISSN (Print) 2194-6329, DOI: 10.1515/jcim-2012-0011, July 2013

Publication History

Received:
2011-09-07
Accepted:
2012-05-17
Published Online:
2013-07-01

Abstract

Chronic kidney disease (CKD) is characterized by a continuous reduction in kidney function, increased inflammation, and reduced antioxidant capacity. The objective of this study was to assess the effects of a herbal supplement on systemic inflammation and antioxidant status in non-dialysis CKD patients. Sixteen patients with CKD (56.0±16.0 yrs, 171.4±11.9 cm, 99.3±20.2 kg) were randomly chosen to receive a herbal supplement composed of Curcuma longa and Boswellia serrata, or placebo. Plasma levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), glutathione peroxidase (GPx), and serum C-reactive protein (CRP) were measured at baseline and 8 weeks. Baseline data demonstrated elevated inflammation and low antioxidant levels. A significant time effect (p=0.03) and time x compliance interaction effect (p=0.04) were observed for IL-6. No significant differences were observed for any other variables. This study demonstrates that mild and moderate CKD is associated with chronic inflammation and low antioxidant activity. Systemic inflammation and impaired antioxidant status may be greater in CKD populations with multiple comorbidities. Curcumin and Boswellia serrata are safe and tolerable and helped to improve the levels of an inflammatory cytokine.

Keywords: chronic kidney disease,; curcumin,; Boswellia serrata,; alternative medicine

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