The successful implementation of homeland security policy requires cooperation among all levels of government—federal, state, and local. The regional approach offers a powerful tool for encouraging greater intergovernmental coordination and improved homeland security readiness. The ability to coordinate preparedness and response activities across multiple jurisdictions is critical to the homeland security mission. In this research we evaluate the regional approach to homeland security coordination using survey data collected from 425 Florida municipal and county government officials and first responders. We identify the primary security concerns of local officials and evaluate the impact of unmet security needs across regions. We also provide analyses of the factors affecting the level of regional security concerns, improvement in intergovernmental cooperation, and ultimately, regional preparedness.