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Journal of Medical Biochemistry

The Journal of Society of Medical Biochemists of Serbia

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Oxidative Stress in Obesity and Metabolic Syndrome in Asian Indians

Nina Veigas1 / Mala Dharmalingam1 / Sara Marcus1

Department of Biochemistry, MSU-GEF International Medical School, Bangalore, India1

Department of Endocrinology, M.S. Ramaiah Medical College and Teaching Hospital, Bangalore, India2

This content is open access.

Citation Information: Journal of Medical Biochemistry. Volume 30, Issue 2, Pages 115–120, ISSN (Online) 1452-8266, ISSN (Print) 1452-8258, DOI: 10.2478/v10011-011-0006-6, January 2011

Publication History

Published Online:
2011-01-28

Oxidative Stress in Obesity and Metabolic Syndrome in Asian Indians

Oxidative stress is associated with the individual components of metabolic syndrome and has been implicated in the development of complications of these metabolic disorders. In this study oxidative stress levels have been compared in obese Indians (a high-risk population for diabetes and cardiovascular disorders) with and without metabolic syndrome. 30 adult normotensive, normoglycemic obese subjects and 35 adults with metabolic syndrome of either sex with BMI >23 kg/m2 were compared with 30 adult, healthy volunteers with BMI <23 kg/m2. Anthropometric parameters, blood pressure, biochemical parameters, hydroperoxides levels and total antioxidant capacity were estimated. The obese groups with and without metabolic syndrome had significantly increased anthropometric parameters like waist circumference and index of central obesity and aqueous phase hydroperoxides when compared with normal controls. The metabolic syndrome group also had significantly increased blood sugar levels, lipid profile and hydroperoxide levels when compared to obese or control groups. There was no alteration in the total antioxidant capacity in any of the groups. The Triglyceride/HDL-Cholesterol ratio (>3), a surrogate marker of insulin resistance, indicates insulin resistance in the metabolic syndrome group. The anthropometric profile, insulin resistance and oxidative stress seen in obesity are further elaborated in metabolic syndrome. Thus, the early identification of high-risk individuals based on anthropometric parameters, lipid profile, insulin resistance and indices of oxidative stress may help to prevent the development of complications of metabolic syndrome.

Oksidativni Stres u Gojaznosti i Metaboličkom Sindromu Kod Indijaca

Oksidativni stres dovodi se u vezu sa pojedinačnim komponentama metaboličkog sindroma i povezan je sa razvojem komplikacija u metaboličkim poremećajima. U ovoj studiji upoređeni su nivoi oksidativnog stresa kod gojaznih Indijaca (populaciji sa visokim rizikom za razvoj dijabetesa i kardiovaskularnih poremećaja) sa i bez metaboličkog sindroma. Trideset odraslih normotenzivnih, normoglikemičnih gojaznih ispitanika i 35 odraslih osoba sa metaboličkim sindromom oba pola sa ITM >23 kg/m2 poređeno je sa 30 odraslih zdravih dobrovoljaca sa ITM <23 kg/m2. Ispitivani su antropometrijski parametri, krvni pritisak, biohemijski parametri, nivoi hidroperoksida i ukupni antioksidantni kapacitet. U gojaznim grupama sa i bez metaboličkog sindroma antropometrijski parametri kao što su obim struka i indeks centralne gojaznosti i aqueous phase hidroperoksidi bili su značajno povišeni u poređenju sa kontrolnim subjektima. Grupa sa metaboličkim sindromom takođe je imala značajno povišene nivoe šećera u krvi, lipidni profil i nivoe hidroperoksida u poređenju sa gojaznom ili kontrolnom grupom. Ni u jednoj grupi nije bilo promena u ukupnom antioksidantnom kapacitetu. Odnos trigliceridi/HDL holesterol (>3), kao surogat marker insulinske rezistencije, ukazuje na rezistenciju na insulin u grupi sa metaboličkim sindromom. Antropometrijski profil, insulinska rezistencija i oksidativni stres prisutni u gojaznosti dalje se razvijaju u metaboličkom sindromu. Otud rana identifikacija osoba sa visokim rizikom na osnovu antropometrijskih parametara, lipidnog profila, insulinske rezistencije i indeksa oksidativnog stresa može doprineti sprečavanju razvoja komplikacija metaboličkog sindroma.

Keywords: obesity; metabolic syndrome; oxidative stress; insulin resistance; hydroperoxides; cardiovascular disorders

Keywords: gojaznost; metabolički sindrom; oksidativni stres; insulinska rezistencija; hidroperoksidi; kardiovaskularni poremećaji

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