Journal of Pediatric Endocrinology and Metabolism
Editor-in-Chief: Kiess, Wieland
Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Roth, Christian / Toppari, Jorma
Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi
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Clinical Presentation and Autoimmune Characteristics of Very Young Children at the Onset of Type 1 Diabetes Mellitus
1Unit of Endocrinology and Diabetes, Bambino Gesù Children's Hospital, University of Rome “Tor Vergata”, Piazza S. Onofrio, Rome, Italy
2Epidemiology Unit, Bambino Gesù Children's Hospital, University of Rome “Tor Vergata”, Piazza S. Onofrio, Rome, Italy
Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 23, Issue 11, Pages 1151–1157, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem.2010.180, December 2010
- Published Online:
The aim of our study was to identify factors that are related to a more aggressive β-cell destruction in children at presentation of type 1 diabetes mellitus (T1D).
We analyzed age, HbA1c, pH, bicarbonate, IAA, IA2, GADA, C peptide of 290 consecutive patients with T1D at onset. Seventy-three (25.2%) were younger than 4 years; 217 (74.8%) were aged 4-18 years. Younger patients had lower C peptide, pH and bicarbonate than older ones. Age at T1D onset was negatively related to IAA titers (r: -0.3404, p < 0.001), positively related to IA2 titers (r: 0.1249, p: 0.03) and to C peptide (r: 0.42, p: < 0.001). Multivariable linear regression showed that C peptide was negatively related to HbA1c and positively related to age, pH at admission and IAA titers.
T1D in very young children is characterized by a more extensive β-cell destruction, and younger age at onset is related to a more severe decompensation.