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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Editorial Board Member: Darendeliler, Feyza / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Lanes M. D., Roberto / Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / LaFranchi, Stephen H. / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Wabitsch, Martin / Werther, George / Zadik, Zvi

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Does Fat Fuel the Fire: Independent and Interactive Effects of Genetic, Physiological, and Environmental Factors on Variations in Fat Deposition and Distribution across Populations

Lynae J. Hanks1 / Krista Casazza1 / Jessica A. Alvarez1 / Jose R. Fernandez12

1Department of Nutrition Sciences and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, AL, USA

2Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA

Corresponding author: Lynae Hanks, MS, RD,

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 23, Issue 12, Pages 1233–1244, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem.2010.197, March 2011

Publication History

Published Online:


Markers of inflammation (MOI) have been reported to influence bone health in adults, with reports of inverse associations. Adipose has also been linked to bone. In children, the interrelationships are unclear. The objective of this study was to evaluate the relationship between MOI (i.e. CRP, TNFR2, IL-6) and bone mineral content (BMC) and determine the contribution of fat deposition/distribution in children. Forty-nine children (59% male) 7-12 y participated. Body composition was evaluated by DXA, and MOI and insulin sensitivity (SI) were obtained during an IVGTT. Multiple linear regression was used for analyses. TNFR2 was inversely associated with BMC. In boys, TNFR2 was inversely associated with BMC, and in girls IL-6 was inversely associated with BMC, and total and percent fat influenced the relationships. Our results suggest a potential inhibitory role of inflammation on bone as well as a negative impact of adiposity. Future investigations are warranted to further investigate these relationships.

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Krista Casazza, Lynae J Hanks, and David A Fields
Bonekey Reports, 2014, Volume 3, Page 577

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