Testosterone, Obesity and Insulin Resistance in Young Males: Evidence for an Association between Gonadal Dysfunction and Insulin Resistance During Puberty : Journal of Pediatric Endocrinology and Metabolism Jump to ContentJump to Main Navigation
Show Summary Details

Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Ed. by Bereket, Abdullah / Cohen, Pinhas / Darendeliler, Feyza / Dattani, Mehul / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Roth, Christian / Toppari, Jorma

Editorial Board Member: Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / Hiort, Olaf / LaFranchi, Stephen H. / Lanes M. D., Roberto / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Werther, George / Zadik, Zvi


IMPACT FACTOR 2015: 0.912

SCImago Journal Rank (SJR) 2015: 0.493
Source Normalized Impact per Paper (SNIP) 2015: 0.600
Impact per Publication (IPP) 2015: 0.955

149,00 € / $224.00 / £112.00*

Online
ISSN
2191-0251
See all formats and pricing

 


Select Volume and Issue
Loading journal volume and issue information...

30,00 € / $42.00 / £23.00

Get Access to Full Text

Testosterone, Obesity and Insulin Resistance in Young Males: Evidence for an Association between Gonadal Dysfunction and Insulin Resistance During Puberty

Megan Moriarty-Kelsey1 / Jeri E. F. Harwood1 / Sharon H. Travers1 / Philip S. Zeitler1 / Kristen J. Nadeau1

1Department of Pediatrics, University of Colorado Denver/The Children's Hospital, 13123 East 16th Avenue, Aurora, CO 80045, USA

Corresponding author: Megan Moriarty-Kelsey, MD,

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 23, Issue 12, Pages 1281–1287, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem.2010.202, March 2011

Publication History

Published Online:
2011-03-02

ABSTRACT

Objective: To assess the relationships among obesity, insulin sensitivity, and testosterone in pubertal boys.

Participants: This study included 20 lean, obese, and type 2 diabetic (T2DM) males, the majority of whom underwent a hyperinsulinemic-euglycemic clamp (n=16).

Methods: Glucose disposal (M value), serum testosterone, and body mass index (BMI) z-score were measured. Differences in testosterone were evaluated by group (lean vs. obese vs. T2DM), while regression was performed to evaluate the relationships among testosterone, obesity and insulin sensitivity.

Results: Controlling for Tanner stage, testosterone concentration was significantly lower in obese (p=0.02) and T2DM males (p=0.001) compared to lean males. Furthermore, M value was significantly associated with serum testosterone, even after controlling for BMI and Tanner stage.

Conclusions: These data suggest that obese adolescent boys have lower serum testosterone than controls of the same Tanner stage, and echo the data in adult males associating obesity and insulin resistance with hypogonadism.

KEY WORDS: insulin resistance; insulin sensitivity; obesity; hypogonadism; puberty; type 2 diabetes mellitus

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Megan M. Kelsey, Petter Bjornstad, Kim McFann, and Kristen Nadeau
Pediatric Diabetes, 2015, Page n/a
[2]
Rosita A. Condorelli, Aldo E. Calogero, Enzo Vicari, Laura Mongioi’, Vincenzo Favilla, Giuseppe Morgia, Sebastiano Cimino, Giorgio Russo, and Sandro La Vignera
Journal of Endocrinological Investigation, 2014, Volume 37, Number 12, Page 1133
[3]
Maria Chondronikola, Walter J. Meyer, Labros S. Sidossis, Sylvia Ojeda, Joanna Huddleston, Pamela Stevens, Elisabet Børsheim, Oscar E. Suman, Celeste C. Finnerty, and David N. Herndon
Journal of Burn Care & Research, 2014, Volume 35, Number 5, Page 409
[4]
Jennifer H. Gunter, Phoebe L. Sarkar, Amy A. Lubik, and Colleen C. Nelson
International Journal of Cell Biology, 2013, Volume 2013, Page 1
[5]
Muniza Mogri, Sandeep Dhindsa, Teresa Quattrin, Husam Ghanim, and Paresh Dandona
Clinical Endocrinology, 2013, Volume 78, Number 4, Page 593
[6]
Hyun-Ah Kim, Sae-Young Lee, Hyuk-Sang Kwon, Seung-Hwan Lee, Min Ho Jung, Kyungdo Han, Hyeon Woo Yim, Won-Chul Lee, and Yong-Moon Park
Diabetes Research and Clinical Practice, 2013, Volume 99, Number 1, Page 54
[7]
Luís Rato, Marco G. Alves, Sílvia Socorro, Ana I. Duarte, José E. Cavaco, and Pedro F. Oliveira
Nature Reviews Urology, 2012, Volume 9, Number 6, Page 330
[8]
Jennifer H. Gunter, Amy A. Lubik, Ian McKenzie, Michael Pollak, and Colleen C. Nelson
Advances in Urology, 2012, Volume 2012, Page 1
[9]
George Yu and Abdulmaged M. Traish
Hormone Molecular Biology and Clinical Investigation, 2011, Volume 8, Number 1

Comments (0)

Please log in or register to comment.