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Journal of Pediatric Endocrinology and Metabolism

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Changes in Dynamic Insulin and Gastrointestinal Hormone Secretion in Obese Children

Christian L. Roth12 / Kathleen D. Bongiovanni12 / Bettina Gohlke2 / Joachim Woelfle2

1Seattle Children's Research Institute, Seattle, USA

2Department of Pediatrics, University of Bonn, Germany

Corresponding author: Christian L. Roth, MD,

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 23, Issue 12, Pages 1299–1309, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem.2010.204, March 2011

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Background: Disturbed satiety and hunger perception in obese individuals has been reported, however data on the dynamic changes of hormonal mediators are sparse.

Objective: To evaluate the secretion pattern of insulin, ghrelin, peptide-YY (PYY), and amylin via 0 to 180 min oral glucose tolerance testing in obese and lean children.

Subjects and Methods: A prospective clinical study was conducted on lean (n=9) and obese (n=20) Caucasian children of comparable age, gender, and pubertal stage. Serial blood samples were collected.

Results: Compared to baseline, levels of acylated ghrelin showed a significant decrease in lean (p<0.05) but not in obese children. PYY increase was blunted and of shorter duration (60 min) in obese children. Amylin levels increased in both groups, and attained significantly higher levels in obese children (p<0.05).

Conclusion: Glucose stimulated gut hormone secretion differed between obese and lean children, and may explain the disturbed satiety observed in obese children.

KEY WORDS: childhood obesity; oral glucose tolerance test; satiety; gut hormone secretion, insulin

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