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Journal of Pediatric Endocrinology and Metabolism

Editor-in-Chief: Kiess, Wieland

Editorial Board Member: Darendeliler, Feyza / Gustafsson, Jan / Luo, Feihong / Mericq, Veronica / Lanes M. D., Roberto / Battelino, Tadej / Buyukgebiz, Atilla / Cassorla, Fernando / Chrousos, George P. / Cutfield, Wayne / Fideleff, Hugo L. / Hershkovitz, Eli / LaFranchi, Stephen H. / Mohn, Angelika / Root, Allen W. / Rosenfeld, Ron G. / Wabitsch, Martin / Werther, George / Zadik, Zvi

12 Issues per year


IMPACT FACTOR 2013: 0.711

SCImago Journal Rank (SJR): 0.334
Source Normalized Impact per Paper (SNIP): 0.423

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Confirmation of Neonatal Screening: Reference Intervals and Evaluation of Methodological Changes in TSH Measurement

Gabriel Fideleff1 / Martha G. Suárez1 / Patricia G. V. Sobrado1 / María L. Celadilla2 / Mario Mardyks3 / Carmen C. Rodriguez3 / Ana Jelen3 / Hugo R. Boquete1 / Hugo L. Fideleff1

1Endocrinology Unit, Department of Medicine, Buenos Aires, Argentina

2Neonatology, Hospital T. Alvarez, Buenos Aires, Argentina

3Neonatology, Hospital V. Sarsfield, Buenos Aires, Argentina

Corresponding author: H.L. Fideleff, MD, PhD.,

Citation Information: Journal of Pediatric Endocrinology and Metabolism. Volume 23, Issue 8, Pages 759–764, ISSN (Online) 2191-0251, ISSN (Print) 0334-018X, DOI: 10.1515/jpem.2010.125, September 2010

Publication History

Published Online:
2010-09-17

ABSTRACT

Neonatal reference values for serum thyrotropin are scarce and comprise only small numbers of patients. During 2006, changes were made in IMMULITE kits for TSH measurement. To validate methodological changes, 80 serum samples from patients were evaluated and to establish reference intervals, 334 neonates and infants were analyzed (divided into 4 groups). Group 1 (G1) (48-72 h of life) (n=153), group 2A (G2A) (7-10 days of life) (n =65), group 2B (G2B) (11- 14 days of life) (n= 35), group 3 (G3) (28-40 days of life) (n =81). Current kits overestimate TSH results by 26 to 37%; TSH (mIU/L) reference intervals (percentile 2.5 – 97.5) were G1 (1.1-12.7), G2A (1.8-9.8), G2B (1.1-7.1) (p<0.03 vs G2A), G3 (1.2-6.9). We suggest that during the second week of life, reference values should be divided into an early stage and a late stage, at least, for there to be an adequate interpretation of borderline measurements in newborn thyroid screening.

KEY WORDS: TSH; thyrotropin; neonatal screening; congenital hypothyroidism; thyroid hormones

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